ArticleBMC musculoskeletal disorders2007
Expression of genes for bone morphogenetic proteins BMP-2, BMP-4 and BMP-6 in various parts of the human skeleton.
Article in BMC musculoskeletal disorders, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
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- Expression of osteogenic molecules in the caudate nucleus and gray matter and their potential relevance for Basal Ganglia calcification in hypoparathyroidism.The Journal of clinical endocrinology and metabolism · 2014Article
- Periarticular bone loss in antigen-induced arthritis.Arthritis and rheumatism · 2013Article
- The effects of low-intensity pulsed ultrasound on tendon-bone healing in a transosseous-equivalent sheep rotator cuff model.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2013Article
- Delivery of siRNA silencing Runx2 using a multifunctional polymer-lipid nanoparticle inhibits osteogenesis in a cell culture model of heterotopic ossification.Integrative biology : quantitative biosciences from nano to macro · 2012Article
- The influence of follistatin on mechanical properties of bone tissue in growing mice with overexpression of follistatin.Journal of bone and mineral metabolism · 2012Article
- Hypoxia inhibits hepcidin expression in HuH7 hepatoma cells via decreased SMAD4 signaling.American journal of physiology. Cell physiology · 2011Article
- Validation of adequate endogenous reference genes for the normalisation of qPCR gene expression data in human post mortem tissue.International journal of legal medicine · 2010Article
- Levels of expression for BMP-7 and several BMP antagonists may play an integral role in a fracture nonunion: a pilot study.Clinical orthopaedics and related research · 2009Article
- Article
- Biology of BMP signalling and cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2009Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDifferences in duration of bone healing in various parts of the human skeleton are common experience for orthopaedic surgeons. The reason for these differences is not obvious and not clear.
methodsIn this paper we decided to measure by the use of real-time RT-PCR technique the level of expression of genes for some isoforms of bone morphogenetic proteins (BMPs), whose role is proven in bone formation, bone induction and bone turnover. Seven bone samples recovered from various parts of skeletons from six cadavers of young healthy men who died in traffic accidents were collected. Activity of genes for BMP-2, -4 and -6 was measured by the use of fluorescent SYBR Green I.
resultsIt was found that expression of m-RNA for BMP-2 and BMP-4 is higher in trabecular bone in epiphyses of long bones, cranial flat bones and corpus mandibulae then in the compact bone of diaphyses of long bones. In all samples examined the expression of m-RNA for BMP-4 was higher than for BMP-2.
conclusionIt was shown that m-RNA for BMP-6 is not expressed in the collected samples at all. It is postulated that differences in the level of activation of genes for BMPs is one of the important factors which determine the differences in duration of bone healing of various parts of the human skeleton.
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