ArticleBMC public health2007
Prevalence of enteropathogenic viruses and molecular characterization of group A rotavirus among children with diarrhea in Dar es Salaam Tanzania.
Article in BMC public health, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Enteric pathogens associated with gastroenteritis among children under 5 years in sub-Saharan Africa: a systematic review and meta-analysis.Epidemiology and infection · 2020Pooled it
- Genetic diversity of circulating rotavirus strains in Tanzania prior to the introduction of vaccination.PloS one · 2014Trial
- Rotavirus Burden, Genetic Diversity and Impact of Vaccine in Children under Five in Tanzania.Pathogens (Basel, Switzerland) · 2019Review
- Prevalence and genotypes of Rotavirus among children under 5 years presenting with diarrhoea in Moshi, Tanzania: a hospital based cross sectional study.BMC research notes · 2017Article
- Etiology of Diarrhea, Nutritional Outcomes, and Novel Intestinal Biomarkers in Tanzanian Infants.Journal of pediatric gastroenterology and nutrition · 2017Article
- Predominance of genotype P[9]G3 in rotavirus gastroenteritis in Polish children.Archives of medical science : AMS · 2015Article
- Molecular genotyping and quantitation assay for rotavirus surveillance.Journal of virological methods · 2015Article
- Frequency of adenoviruses, rotaviruses and noroviruses among diarrhea samples collected from infants of zabol, southeastern iran.Jundishapur journal of microbiology · 2015Article
- Viral Agents of Diarrhea in Young Children in Two Primary Health Centers in Edo State, Nigeria.International journal of microbiology · 2015Article
- Prevalence and molecular characterisation of human adenovirus in diarrhoeic children in Tanzania; a case control study.BMC infectious diseases · 2014Article
- Predominance of rotavirus G1[P8] genotype among under-five children with gastroenteritis in Mwanza, Tanzania.Journal of tropical pediatrics · 2014Article
- Community knowledge and attitudes and health workers' practices regarding non-malaria febrile illnesses in eastern Tanzania.PLoS neglected tropical diseases · 2014Article
- Association between stool enteropathogen quantity and disease in Tanzanian children using TaqMan array cards: a nested case-control study.The American journal of tropical medicine and hygiene · 2014Article
- Sociocultural determinants of anticipated vaccine acceptance for acute watery diarrhea in early childhood in Katanga Province, Democratic Republic of Congo.The American journal of tropical medicine and hygiene · 2013Article
- Bacterial and viral etiology of childhood diarrhea in Ouagadougou, Burkina Faso.BMC pediatrics · 2013Article
- Burden and typing of rotavirus group a in children with acute gastroenteritis in shiraz, southern iran.Iranian Red Crescent medical journal · 2012Article
- Comparative evaluation of the potential impact of rotavirus versus HPV vaccination in GAVI-eligible countries: a preliminary analysis focused on the relative disease burden.BMC infectious diseases · 2011Article
- Pathogenic microorganisms associated with childhood diarrhea in low-and-middle income countries: case study of Yaoundé - Cameroon.International journal of environmental research and public health · 2008Article
- Importance of viral pathogens in children with acute gastroenteritis in the south of Iran.Annals of Saudi medicineArticle
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDifferent groups of viruses have been shown to be responsible for acute diarrhea among children during their first few years of life. Epidemiological knowledge of viral agents is critical for the development of effective preventive measures, including vaccines.
methodsIn this study we determined the prevalence of the four major enteropathogenic viruses - rotavirus, norovirus, adenovirus and astrovirus - was determined in 270 stool samples collected from children aged 0 - 60 months who were admitted with diarrhea in four hospitals in Dar es Salaam, Tanzania, using commercially available ELISA kits. In addition, the molecular epidemiology of group A rotavirus was investigated using reverse transcriptase multiplex polymerase chain reaction (RT-PCR).
resultsAt least one viral agent was detected in 87/270 (32.2%) of the children. The prevalence of rotavirus, norovirus, adenovirus and astrovirus was 18.1%, 13.7%, 2.6% and 0.4%, respectively. In most cases (62.1%) of viruses were detected in children aged 7-12 months. The G and P types (VP7 and VP4 genotypes respectively) were further investigated in 49 rotavirus ELISA positive samples. G9 was the predominant G type (81.6%), followed by G1 (10.2%) and G3 (0.2%). P[8] was the predominant P type (83.7%), followed by P[6] (0.4%) and P[4] (0.2%). The following G and P types were not detected in this study population; G2, G4, G8 G10, P[9], P[10] and P[11]. The dominating G/P combination was G9P[8], accounting for 39 (90.7%) of the 43 fully characterized strains. Three (6.1%) of the 49 rotavirus strains could not be typed.
conclusionNearly one third of children with diarrhea admitted to hospitals in Dar es Salaam had one of the four viral agents. The predominance of rotavirus serotype G9 may have implication for rotavirus vaccination in Tanzania.
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