ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2008
Risk factors for rejection and infection in pediatric liver transplantation.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 150 citations in OpenAlex.
- Etiology and management of cholangitis in pediatric liver transplant recipients: a systematic review.Current opinion in organ transplantation · 2026Pooled it
- Burden of infectious diseases in children during the first year after solid organ transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Comparison of the incidence of reperfusion syndrome and outcomes of liver transplantation among pediatric recipients of partial vs. whole graft: report of six-year retrospective study.BMC anesthesiology · 2025Observational
- Characteristics and Outcome of Partial Liver Transplant among Pediatrics in a Referral Transplant Center in Iran from 2010 to 2020.Iranian journal of medical sciences · 2025Article
- Incidence, causative organisms, and risk factors of bloodstream infections in pediatric liver transplant patients: a systematic review.Clinical and experimental pediatrics · 2024Article
- Postoperative Bloodstream Infection Is Associated with Early Vascular Complications in Pediatric Liver Transplant Recipients with Biliary Atresia.Journal of clinical medicine · 2023Article
- Epidemiology and Risk Factors for Viral Infections in Pediatric Liver Transplant Recipients and Impact on Outcome.Viruses · 2023Review
- The Role of Pretransplant Infections in Pediatric Receiving LDLT in Indonesia: A 7-y Retrospective Study.Transplantation direct · 2023Article
- A European International Multicentre Survey on the Current Practice of Perioperative Antibiotic Prophylaxis for Paediatric Liver Transplantations.Antibiotics (Basel, Switzerland) · 2023Article
- Pediatric living donor liver transplantation (LDLT): Short- and long-term outcomes during sixteen years period at a single centre- A retrospective cohort study.Annals of medicine and surgery (2012) · 2022Article
- Immunologic benefits of maternal living donor allografts in pediatric liver transplantation: fewer rejection episodes and no evidence of de novo allosensitization.Pediatric transplantation · 2022Article
- A network-based approach to identify expression modules underlying rejection in pediatric liver transplantation.Cell reports. Medicine · 2022Article
- Assessment of pathogens and risk factors associated with bloodstream infection in the year after pediatric liver transplantation.World journal of gastroenterology · 2022Article
- Recurrence of Primary Sclerosing Cholangitis After Liver Transplant in Children: An International Observational Study.Hepatology (Baltimore, Md.) · 2021Observational
- Bacterial and fungal bloodstream infections in pediatric liver and kidney transplant recipients.BMC infectious diseases · 2021Article
- The Human Immune Response to Cadaveric and Living Donor Liver Allografts.Frontiers in immunology · 2020Review
- Evidence of Chronic Allograft Injury in Liver Biopsies From Long-term Pediatric Recipients of Liver Transplants.Gastroenterology · 2018Article
- Predicting Cellular Rejection With a Cell-Based Assay: Preclinical Evaluation in Children.Transplantation · 2017Article
- Systemic hemodynamics in advanced cirrhosis: Concerns during perioperative period of liver transplantation.World journal of hepatology · 2016Review
- Molecular appraisal of intestinal parasitic infection in transplant recipients.The Indian journal of medical research · 2016Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Rejection and infection are important adverse events after pediatric liver transplantation, not previously subject to concurrent risk analysis. Of 2291 children (<18 years), rejection occurred at least once in 46%, serious bacterial/fungal or viral infections in 52%. Infection caused more deaths than rejection (5.5% vs. 0.6% of patients, p < 0.001). Early rejection (<6 month) did not contribute to mortality or graft failure. Recurrent/chronic rejection was a risk in graft failure, but led to retransplant in only 1.6% of first grafts. Multivariate predictors of bacterial/fungal infection included recipient age (highest in infants), race, donor organ variants, bilirubin, anhepatic time, cyclosporin (vs. tacrolimus) and era of transplant (before 2002 vs. after 2002); serious viral infection predictors included donor organ variants, rejection, Epstein-Barr Virus (EBV) naivety and era; for rejection, predictors included age (lowest in infants), primary diagnosis, donor-recipient blood type mismatch, the use of cyclosporin (vs. tacrolimus), no induction and era. In pediatric liver transplantation, infection risk far exceeds that of rejection, which causes limited harm to the patient or graft, particularly in infants. Aggressive infection control, attention to modifiable factors such as pretransplant nutrition and donor organ options and rigorous age-specific review of the risk/benefit of choice and intensity of immunosuppressive regimes is warranted.
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