Evidence map›Paper›PMID 18162039›Full record

ArticlePLoS medicine2007

The challenges of Chagas Disease-- grim outlook or glimmer of hope.

Rick L Tarleton, Richard Reithinger, Julio A Urbina, Uriel Kitron, Ricardo E Gürtler

Registry-linked trialAbstract read
In one paragraph

Article in PLoS medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03981523 (New Chemotherapy Regimens and Biomarkers for Chagas Disease), which is not on this map. Cited by 106 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03981523 phase2completednot on this mapstarted 2019, after this paper: background citation

New Chemotherapy Regimens and Biomarkers for Chagas Disease

TypeinterventionalSponsorUniversity of Texas, El PasoRan2019 to 2024Enrolled450ConditionsTrypanosoma Cruzi Infection, Chagas DiseaseArmsBenznidazole, Nifurtimox
3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Changes in Trypanosoma cruzi-specific immune responses after treatment: surrogate markers of treatment efficacy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2009
    Trial
  4. Current tropical medicine reports · 2023
    Article
  5. Article
  6. Article
  7. Chagas disease in Oklahoma.The American journal of the medical sciences · 2022
    Review
  8. Article
  9. How is global change affecting Chagas disease landscapes?Memorias do Instituto Oswaldo Cruz · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Diagnosis ofThe American journal of tropical medicine and hygiene · 2018
    Article

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rick L TarletonCenter for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America. tarleton@cb.uga.edu
Richard Reithinger
Julio A Urbina
Uriel Kitron
Ricardo E Gürtler

Funding

VACCINE DISCOVERY FOR TRYPANOSOMA CRUZIP01AI044979 · NIAID · UNIVERSITY OF GEORGIA (UGA) · PI TARLETON, RICK L · 1999 to 2008
$7.5M
IMMUNOREGULATION IN EXPERIMENTAL CHAGAS'DISEASER01AI022070 · NIAID · UNIVERSITY OF GEORGIA (UGA) · PI TARLETON, RICK L · 1985 to 2011
$3.2M
CD8+ T-CELLS AND TRYPANOSOMA CRUZI INFECTIONSR01AI033106 · NIAID · UNIVERSITY OF GEORGIA (UGA) · PI TARLETON, RICK L · 1994 to 2009
$2.8M
Ecoepidemiology of Chagas disease in northwest ArgentinaR01TW005836 · FIC · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI KITRON, URIEL DAN · 2002 to 2006
$2.0M
FIC NIH HHS R01 TW005836FIC NIH HHS R01 TW05836NIAID NIH HHS P01 AI-044979NIAID NIH HHS P01 AI044979NIAID NIH HHS R01 AI-022070NIAID NIH HHS R01 AI022070NIAID NIH HHS R01 AI-033106NIAID NIH HHS R01 AI033106
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Orphan Drug ProductionProtozoan VaccinesAnimalsAntiparasitic AgentsChagas CardiomyopathyChagas DiseaseCommunicable Disease ControlDisease VectorsHumansRare DiseasesSouth AmericaTrypanosoma cruziAntiparasitic AgentsProtozoan Vaccines

Identifiers

PMID18162039
PMCPMC2222930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.