ArticleJournal of biomedical materials research. Part B, Applied biomaterials2008
Adhesion to chondroitinase ABC treated dentin.
Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Effects and Properties of Deproteinizing Methods in Dentin: A Comprehensive Narrative Review.Journal of functional biomaterials · 2026Review
- Improving bonding to eroded dentin by using collagen cross-linking agents: 2 years of water storage.Clinical oral investigations · 2020Article
- Structural and biomechanical changes to dentin extracellular matrix following chemical removal of proteoglycans.Odontology · 2019Article
- The Effect of SnClBioMed research international · 2018Article
- Biostability of the Proanthocyanidins-Dentin Complex and Adhesion Studies.Journal of dental research · 2017Article
- Dental adhesives and strategies for displacement of water/solvents from collagen fibrils.Dental materials : official publication of the Academy of Dental Materials · 2016Article
- Dentin biomodification: strategies, renewable resources and clinical applications.Dental materials : official publication of the Academy of Dental Materials · 2014Review
- Strategies to prevent hydrolytic degradation of the hybrid layer-A review.Dental materials : official publication of the Academy of Dental Materials · 2013Review
- The effect of a tin-containing fluoride mouth rinse on the bond between resin composite and erosively demineralised dentin.Clinical oral investigations · 2013Article
- The dentin organic matrix - limitations of restorative dentistry hidden on the nanometer scale.Acta biomaterialia · 2012Review
- Characterization of biomodified dentin matrices for potential preventive and reparative therapies.Acta biomaterialia · 2011Article
- State of the art etch-and-rinse adhesives.Dental materials : official publication of the Academy of Dental Materials · 2011Review
- Ethanol wet-bonding challenges current anti-degradation strategy.Journal of dental research · 2010Article
- Functional biomimetic analogs help remineralize apatite-depleted demineralized resin-infiltrated dentin via a bottom-up approach.Acta biomaterialia · 2010Article
- Two-photon laser confocal microscopy of micropermeability of resin-dentin bonds made with water or ethanol wet bonding.Journal of biomedical materials research. Part B, Applied biomaterials · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Dentin bonding relies on complete resin impregnation throughout the demineralised hydrophilic collagen mesh. Chondroitin sulphate-glycosaminoglycans are claimed to regulate the three-dimensional arrangement of the dentin organic matrix and its hydrophilicity. The aim of this study was to investigate bond strength of two etch-and-rinse adhesives to chondroitinase ABC treated dentin. Human extracted molars were treated with chondroitinase ABC and a double labeling immunohistochemical technique was applied to reveal type I collagen and chondroitin 4/6 sulphate distribution under field emission in-lens scanning electron microscope. The immunohistochemical technique confirmed the effective removal of chondroitin 4/6 sulphate after the enzymatic treatment. Dentin surfaces exposed to chondroitinase ABC and untreated specimens prepared on untreated acid-etched dentin were bonded with Adper Scotchbond Multi-Purpose or Prime and Bond NT. Bonded specimens were submitted to microtensile testing and nanoleakage interfacial analysis under transmission electron microscope. Increased mean values of microtensile bond strength and reduced nanoleakage expression were found for both adhesives after chondroitinase ABC treatment of the dentin surface. Adper Scotchbond Multi-Purpose increased its bond strength about 28%, while bonding made with Prime and Bond NT almost doubled (92% increase) compared to untreated specimens. This study supports the hypothesis that adhesion can be enhanced by removal of chondroitin 4/6 sulphate and dermatan sulphate, probably due to a reduced amount of water content and enlarged interfibrillar spaces. Further studies should validate this hypothesis investigating the stability of chondroitin 4/6 and dermatan sulphate-depleted dentin bonded interface over time.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.