ArticleBiophysical journal2008
A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 225 papers.
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Who cites it
225 citing papers in PubMed.
- Variable expressivity in long QT syndrome type 2 rabbits defines a low threshold for therapeuticAmerican journal of physiology. Heart and circulatory physiology · 2026Article
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- Gerrymandering in the heart: How tissue heterogeneities promote premature ventricular contractions.Biophysical journal · 2026Article
- Models of cardiomyocyte-non-myocyte electrical interactions.The Journal of physiology · 2026Review
- Multiscale stochastic modeling for calcium dynamics in cardiac electrophysiology: assessing whole-cell model reliability under phosphorylation and LCC downregulation.Frontiers in network physiology · 2026Article
- The electrophysiology of ventricular cell pairs.Pflugers Archiv : European journal of physiology · 2025Review
- Evidence for intermittent coupling of intramyocardial small, engineered heart tissues acutely implanted into rabbit myocardium.Cardiovascular research · 2025Article
- Role of dynamical instability in QT interval variability and early afterdepolarization propensity.Biophysical journal · 2025Article
- Impact of Calcium and Potassium Currents on Spiral Wave Dynamics in the LR1 Model.Entropy (Basel, Switzerland) · 2025Article
- Mechanism of Arrhythmogenesis Driven by Early After Depolarizations in Cardiac Tissue.PLoS computational biology · 2025Article
- A large population of cell-specific action potential models replicating fluorescence recordings of voltage in rabbit ventricular myocytes.Royal Society open science · 2025Article
- Modeling autoregulation of cardiac excitation-Ca-contraction and arrhythmogenic activities in response to mechanical load changes.iScience · 2025Article
- Acute ischaemia and gap junction modulation modify propagation patterns across Purkinje-myocardial junctions.Frontiers in physiology · 2025Article
- Article
- Reconstructing ventricular cardiomyocyte dynamics and parameter estimation using data assimilation.Biophysical journal · 2024Article
- Role of ryanodine receptor cooperativity in CaThe Journal of physiology · 2024Article
- A novel computational model of swine ventricular myocyte reveals new insights into disease mechanisms and therapeutic approaches in Timothy Syndrome.Scientific reports · 2024Article
- Cardiac function is regulated by the sodium-dependent inhibition of the sodium-calcium exchanger NCX1.Nature communications · 2024Article
- A biochemical description of postsynaptic plasticity-with timescales ranging from milliseconds to seconds.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
165 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors.
Funding
Abstract
Mathematical modeling of the cardiac action potential has proven to be a powerful tool for illuminating various aspects of cardiac function, including cardiac arrhythmias. However, no currently available detailed action potential model accurately reproduces the dynamics of the cardiac action potential and intracellular calcium (Ca(i)) cycling at rapid heart rates relevant to ventricular tachycardia and fibrillation. The aim of this study was to develop such a model. Using an existing rabbit ventricular action potential model, we modified the L-type calcium (Ca) current (I(Ca,L)) and Ca(i) cycling formulations based on new experimental patch-clamp data obtained in isolated rabbit ventricular myocytes, using the perforated patch configuration at 35-37 degrees C. Incorporating a minimal seven-state Markovian model of I(Ca,L) that reproduced Ca- and voltage-dependent kinetics in combination with our previously published dynamic Ca(i) cycling model, the new model replicates experimentally observed action potential duration and Ca(i) transient alternans at rapid heart rates, and accurately reproduces experimental action potential duration restitution curves obtained by either dynamic or S1S2 pacing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.