Evidence map›Paper›PMID 18160652›Full record

Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2007

Focusing effect of acetylcholine on neuroplasticity in the human motor cortex.

Min-Fang Kuo, Jan Grosch, Felipe Fregni, Walter Paulus, Michael A Nitsche

Open access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 6 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 6 syntheses or guidelines pooled it, 208 citations in OpenAlex.

  1. Pooled it
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  11. Pharmacological Manipulation of Cortical Inhibition in the Dorsolateral Prefrontal Cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
    Trial
  12. Trial
  13. Effect of serotonin on paired associative stimulation-induced plasticity in the human motor cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013
    Trial
  14. Neuroplasticity in cigarette smokers is altered under withdrawal and partially restituted by nicotine exposition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012
    Trial
  15. Neuromodulatory neurotransmitters influence LTP-like plasticity in human cortex: a pharmaco-TMS study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011
    Trial
  16. Nicotinergic impact on focal and non-focal neuroplasticity induced by non-invasive brain stimulation in non-smoking humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011
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  19. Article
  20. Review

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Min-Fang KuoDepartment of Clinical Neurophysiology, Georg-August-University Göttingen, 37075 Göttingen, Germany.
Jan Grosch
Felipe Fregni
Walter Paulus
Michael A Nitsche
University of Göttingen · DEBerenson Allen Center for Noninvasive Brain Stimulation · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cholinergic neuromodulation is pivotal for arousal, attention, and cognitive processes. Loss or dysregulation of cholinergic inputs leads to cognitive impairments like those manifested in Alzheimer's disease. Such dysfunction can be at least partially restored by an increase of acetylcholine (ACh). In animal studies, ACh selectively facilitates long-term excitability changes induced by feed-forward afferent input. Consequently, it has been hypothesized that ACh enhances the signal-to-noise ratio of input processing. However, the neurophysiological foundation for its ability to enhance cognition in humans is not well documented. In this study we explore the effects of rivastigmine, a cholinesterase inhibitor, on global and synapse-specific forms of cortical plasticity induced by transcranial direct current stimulation (tDCS) and paired associative stimulation (PAS) on 10-12 healthy subjects, respectively. Rivastigmine essentially blocked the induction of the global excitability enhancement elicited by anodal tDCS and revealed a tendency to first reduce and then stabilize cathodal tDCS-induced inhibitory aftereffects. However, ACh enhanced the synapse-specific excitability enhancement produced by facilitatory PAS and consolidated the inhibitory PAS-induced excitability diminution. These findings are in line with a cholinergic focusing effect that optimizes the detection of relevant signals during information processing in humans.

Indexed as

AcetylcholineAdultAnalysis of VarianceCholinesterase InhibitorsElectric StimulationEvoked Potentials, MotorFemaleHumansMaleMotor CortexNeuronal PlasticityPhenylcarbamatesRivastigmineTime FactorsTranscranial Magnetic StimulationAcetylcholineCholinesterase InhibitorsPhenylcarbamatesRivastigmine

Identifiers

PMID18160652
PMCPMC6673455
OpenAlexW2102271526

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.