ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Olig1 and Sox10 interact synergistically to drive myelin basic protein transcription in oligodendrocytes.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.
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Who cites it
106 citing papers in PubMed, 173 citations in OpenAlex.
- Rapid Generation of Functional Oligodendrocytes From Human Induced Pluripotent Stem Cells Through Small Molecule Guided Differentiation.Journal of neuroscience research · 2026Article
- Histone demethylase KDM6B promotes postnatal oligodendrocyte maturation and cortical myelination.Frontiers in cellular neuroscience · 2026Article
- MEP glia share molecular features with oligodendrocytes while maintaining a distinct hybrid signature.microPublication biology · 2026Article
- SOX Genes in Spinal Cord Injury: Redefining Neural Stem Cell Regeneration Strategies.Molecular neurobiology · 2025Review
- Spinal Cord Injury Remyelination: Pathways to Therapies.International journal of molecular sciences · 2025Review
- Demyelination and Remyelination: General Principles.Advances in neurobiology · 2025Review
- Shared patterns of glial transcriptional dysregulation link Huntington's disease and schizophrenia.Brain : a journal of neurology · 2024Article
- Systemic and intrinsic functions of ATRX in glial cell fate and CNS myelination in male mice.Nature communications · 2023Article
- ANGPTL2 binds MAG to efficiently enhance oligodendrocyte differentiation.Cell & bioscience · 2023Article
- KLF9 and KLF13 transcription factors boost myelin gene expression in oligodendrocytes as partners of SOX10 and MYRF.Nucleic acids research · 2022Article
- Recent advances in the regulation mechanism ofJournal of otology · 2022Review
- Human IL12p80 Promotes Murine Oligodendrocyte Differentiation to Repair Nerve Injury.International journal of molecular sciences · 2022Article
- Effects of prenatal exposure to inflammation coupled with prepubertal stress on prefrontal white matter structure and related molecules in adult mouse offspring.Metabolic brain disease · 2022Article
- Genetic Regulation of Vertebrate Forebrain Development by Homeobox Genes.Frontiers in neuroscience · 2022Review
- The Effects of the Olig Family on the Regulation of Spinal Cord Development and Regeneration.Neurochemical research · 2021Review
- Thyroid hormone deficiency during zebrafish development impairs central nervous system myelination.PloS one · 2021Article
- Proteome Profile of Myelin in the Zebrafish Brain.Frontiers in cell and developmental biology · 2021Article
- Meta-Analysis Reveals Transcription Factor Upregulation in Cells of Injured Mouse Sciatic Nerve.Frontiers in cellular neuroscience · 2021Article
- Insights Into Central Nervous System Glial Cell Formation and Function From Zebrafish.Frontiers in cell and developmental biology · 2021Review
- Olig2 SUMOylation protects against genotoxic damage response by antagonizing p53 gene targeting.Cell death and differentiation · 2020Article
46 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The oligodendrocyte lineage genes (Olig1/2), encoding basic helix-loop-helix transcription factors, were first identified in screens for master regulators of oligodendrocyte development. OLIG1 is important for differentiation of oligodendrocyte precursors into myelin-forming oligodendrocytes during development and is thought to play a crucial role in remyelination during multiple sclerosis. However, it is still unclear how OLIG1 interacts with its transcriptional cofactors and DNA targets. OLIG1 was reportedly restricted to mammals, but we demonstrate here that zebrafish and other teleosts also possess an OLIG1 homolog. In zebrafish, as in mammals, Olig1 is expressed in the oligodendrocyte lineage. Olig1 associates physically with another myelin-associated transcription factor, Sox10, and the Olig1/Sox10 complex activates mbp (myelin basic protein) transcription via conserved DNA sequence motifs in the mbp promoter region. In contrast, Olig2 does not bind to Sox10 in zebrafish, although both OLIG1 and OLIG2 bind SOX10 in mouse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.