Evidence map›Paper›PMID 18160467›Full record

ArticleThe Journal of clinical endocrinology and metabolism2008

Bone mineral density changes during the menopause transition in a multiethnic cohort of women.

Joel S Finkelstein, Sarah E Brockwell, Vinay Mehta, Gail A Greendale, MaryFran R Sowers, Bruce Ettinger, Joan C Lo, Janet M Johnston, Jane A Cauley, Michelle E Danielson and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05961371 (Strength Training for Osteoporosis Prevention During Early Menopause), which is not on this map. Cited by 294 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
294citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05961371 naactive not recruitingnot on this mapstarted 2023, after this paper: background citation

Strength Training for Osteoporosis Prevention During Early Menopause

TypeinterventionalSponsorUniversity of CalgaryRan2023 to 2025Enrolled40ConditionsBone Loss, Bone Loss, Age-related, Osteoporosis, Musculoskeletal DiseasesArmsResistance Training
3 · Its place in the literature

Who cites it

294 citing papers in PubMed, 12 syntheses or guidelines pooled it.

  1. Pooled it
  2. Effectiveness and safety of bone protective interventions to mitigate bone loss and skeletal fractures experienced by patients with non-metastatic breast cancer: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
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  9. Association between a literature-based genetic risk score and bone mineral density of African American women in Women Health Initiative Study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020
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  13. Efficacy of zoledronic acid in peri-menopausal women with osteopenia.Journal of bone and mineral metabolism · 2026
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234 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Joel S FinkelsteinEndocrine Unit, Department of Medicine, Massachusetts General Hospital, 50 Blossom Street, Boston, Massachusetts 02114, USA. jfinkelstein@partners.org
Sarah E Brockwell
Vinay Mehta
Gail A Greendale
MaryFran R Sowers
Bruce Ettinger
Joan C Lo
Janet M Johnston
Jane A Cauley
Michelle E Danielson
Robert M Neer

Funding

WOMENS HEALTH ACROSS THE NATION--COORDINATING CENTERU01AG012553 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BROOKS, MARIA MORI · 1994 to 2019
$37.7M
WOMENS HEALTH ACROSS THE NATION--ENDOCRINE LABU01AG012495 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCONNELL, DANIEL S · 1994 to 2018
$18.8M
WOMENS HEALTH ACROSS THE NATION--PITTSBURGHU01AG012546 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MATTHEWS, KAREN · 1994 to 2019
$16.2M
WOMENS HEALTH ACROSS THE NATION--UCDAVISU01AG012554 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI GOLD, ELLEN B. · 1994 to 2019
$14.5M
WOMENS HEALTH ACROSS THE NATION--UCLAU01AG012539 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREENDALE, GAIL A · 1994 to 2018
$13.7M
THE STUDY OF WOMEN'S HEALTH ACROSS THE NATION-MICHIGANU01NR004061 · NINR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARLOW, SIOBAN D · 1994 to 2018
$12.9M
WOMENS HEALTH ACROSS THE NATION--CHICAGOU01AG012505 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI KRAVITZ, HOWARD M · 1994 to 2019
$11.9M
WOMENS HEALTH ACROSS THE NATION--MASSACHUSETTS GENERAL HU01AG012531 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI FINKELSTEIN, JOEL S · 1994 to 2019
$10.7M
Women's Health Across the Nation-New Jersey SiteU01AG012535 · NIA · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI DERBY, CAROL A. · 1994 to 2019
$9.2M
EFFECTS OF ANDROGENS, ESTROGENS, AND PTH ON BONEK24DK002759 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FINKELSTEIN, JOEL S · 1999 to 2008
$1.2M
NIA NIH HHS AG012495NIA NIH HHS AG012505NIA NIH HHS AG012531NIA NIH HHS AG012535NIA NIH HHS AG012539NIA NIH HHS AG012546NIA NIH HHS AG012553NIA NIH HHS AG012554NIA NIH HHS U01 AG012495NIA NIH HHS U01 AG012505NIA NIH HHS U01 AG012531NIA NIH HHS U01 AG012535NIA NIH HHS U01 AG012539NIA NIH HHS U01 AG012546NIA NIH HHS U01 AG012553NIA NIH HHS U01 AG012554NIDDK NIH HHS K24 DK002759NIDDK NIH HHS K24 DK02759NINR NIH HHS NR004061NINR NIH HHS U01 NR004061
6 · The paper itself

Abstract

contextRates of bone loss across the menopause transition and factors associated with variation in menopausal bone loss are poorly understood.

objectiveOur objective was to assess rates of bone loss at each stage of the transition and examine major factors that modify those rates. DESIGN, SETTING, AND

participantsWe conducted a longitudinal cohort study of 1902 African-American, Caucasian, Chinese, or Japanese women participating in The Study of Women's Health Across the Nation. Women were pre- or early perimenopausal at baseline. OUTCOME MEASURE: We assessed bone mineral density (BMD) of the lumbar spine and total hip across a maximum of six annual visits.

resultsThere was little change in BMD during the pre- or early perimenopause. BMD declined substantially in the late perimenopause, with an average loss of 0.018 and 0.010 g/cm2.yr from the spine and hip, respectively (P<0.001 for both). In the postmenopause, rates of loss from the spine and hip were 0.022 and 0.013 g/cm2.yr, respectively (P<0.001 for both). During the late peri- and postmenopause, bone loss was approximately 35-55% slower in women in the top vs. the bottom tertile of body weight. Apparent ethnic differences in rates of spine bone loss were largely explained by differences in body weight.

conclusionsBone loss accelerates substantially in the late perimenopause and continues at a similar pace in the first postmenopausal years. Body weight is a major determinant of the rate of menopausal BMD loss, whereas ethnicity, per se, is not. Healthcare providers should consider this information when deciding when to screen women for osteoporosis.

Indexed as

Bone DensityAsian PeopleBlack or African AmericanBody WeightCohort StudiesFemaleHumansLongitudinal StudiesMenopauseMiddle AgedWhite People

Identifiers

PMID18160467
PMCPMC2266953

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.