ArticleJournal of virology2008
Genetic determinants of Sindbis virus mosquito infection are associated with a highly conserved alphavirus and flavivirus envelope sequence.
Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Structural and Functional Hallmarks of Sindbis Virus Proteins: From Virion Architecture to Pathogenesis.International journal of molecular sciences · 2025Review
- Prophylactic strategies to control chikungunya virus infection.Virus genes · 2021Review
- Complexity of virus-vector interactions.Current opinion in virology · 2016Review
- Tissue Barriers to Arbovirus Infection in Mosquitoes.Viruses · 2015Review
- Exposure of epitope residues on the outer face of the chikungunya virus envelope trimer determines antibody neutralizing efficacy.Journal of virology · 2014Article
- Isolation of midgut escape mutants of two American genotype dengue 2 viruses from Aedes aegypti.Virology journal · 2013Article
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- Article
- Molecular determinants of mouse neurovirulence and mosquito infection for Western equine encephalitis virus.PloS one · 2013Article
- Effects of manipulating apoptosis on Sindbis virus infection of Aedes aegypti mosquitoes.Journal of virology · 2012Article
- Genotypic and phenotypic characterization of Chikungunya virus of different genotypes from Malaysia.PloS one · 2012Article
- Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography.Nature · 2010Article
- Molecular characterization of Chikungunya virus isolates from clinical samples and adult Aedes albopictus mosquitoes emerged from larvae from Kerala, South India.Virology journal · 2010Article
- Epistatic roles of E2 glycoprotein mutations in adaption of chikungunya virus to Aedes albopictus and Ae. aegypti mosquitoes.PloS one · 2009Article
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3 authors.
Funding
Abstract
Wild-type Sindbis virus (SINV) strain MRE16 efficiently infects Aedes aegypti midgut epithelial cells (MEC), but laboratory-derived neurovirulent SINV strain TE/5'2J infects MEC poorly. SINV determinants for MEC infection have been localized to the E2 glycoprotein. The E2 amino acid sequences of MRE16 and TE/5'2J differ at 60 residue sites. To identify the genetic determinants of MEC infection of MRE16, the TE/5'2J virus genome was altered to contain either domain chimeras or more focused nucleotide substitutions of MRE16. The growth patterns of derived viruses in cell culture were determined, as were the midgut infection rates (MIR) in A. aegypti mosquitoes. The results showed that substitutions of MRE16 E2 aa 95 to 96 and 116 to 119 into the TE/5'2J virus increased MIR both independently and in combination with each other. In addition, a unique PPF/.GDS amino acid motif was located between these two sites that was found to be a highly conserved sequence among alphaviruses and flaviviruses but not other arboviruses.
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