ReviewMechanisms of ageing and development
The role of telomere biology in bone marrow failure and other disorders.
Review in Mechanisms of ageing and development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 73 citations in OpenAlex.
- Danazol Treatment for Telomere Diseases.The New England journal of medicine · 2016Trial
- A natural product telomerase activator as part of a health maintenance program.Rejuvenation research · 2011Trial
- Molecular alterations in the GATA-2, RUNX1, C/EBPα and hTERT genes in patients with aplastic anemia by MLPA.Genetics and molecular biology · 2026Article
- Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo.GeroScience · 2023Article
- Telomere biology: from disorders to hematological diseases.Frontiers in oncology · 2023Review
- No association between telomere length and osteonecrosis of the femoral head.BMC musculoskeletal disorders · 2021Article
- No association between donor telomere length and outcomes after allogeneic unrelated hematopoietic cell transplant in patients with acute leukemia.Bone marrow transplantation · 2018Article
- Fanconi Anemia: A DNA repair disorder characterized by accelerated decline of the hematopoietic stem cell compartment and other features of aging.Ageing research reviews · 2017Review
- Fanconi anemia proteins in telomere maintenance.DNA repair · 2016Review
- Telomere Length and the Cancer-Atherosclerosis Trade-Off.PLoS genetics · 2016Review
- Serum Interleukin-6 Levels and Pulmonary Function in Ataxia-Telangiectasia.The Journal of pediatrics · 2016Article
- Article
- Involvement of SRSF11 in cell cycle-specific recruitment of telomerase to telomeres at nuclear speckles.Nucleic acids research · 2015Article
- Outcomes of allogeneic hematopoietic cell transplantation in patients with dyskeratosis congenita.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2013Article
- Multiple genetic pathways regulate replicative senescence in telomerase-deficient yeast.Aging cell · 2013Article
- Article
- The interaction between the yeast telomerase RNA and the Est1 protein requires three structural elements.RNA (New York, N.Y.) · 2012Article
- TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends.Cell · 2012Article
- Abnormal telomere shortening of peripheral blood mononuclear cells and granulocytes in patients with chronic idiopathic neutropenia.Haematologica · 2012Article
- Telomere biology in hematopoiesis and stem cell transplantation.Blood reviews · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Telomeres, consisting of nucleotide repeats and a protein complex at chromosome ends, are essential in maintaining chromosomal integrity. Dyskeratosis congenita (DC) is the inherited bone marrow failure syndrome (IBMFS) that epitomizes the effects of abnormal telomere biology. Patients with DC have extremely short telomere lengths (<1st percentile) and many have mutations in telomere biology genes. Interpretation of telomere length in other IBMFSs is less straightforward. Abnormal telomere shortening has been reported in patients with apparently acquired hematologic disorders, including aplastic anemia, myeolodysplasia, paroxysmal nocturnal hemoglobinuria, and leukemia. In these disorders, the shortest-lived cells have the shortest telomeres, suggestive of increased hematopoietic stress. Telomeres are also markers of replicative and/or oxidative stress in other complex disease pathways, such as inflammation, stress, and carcinogenesis. The spectrum of related disorders caused by mutations in telomere biology genes extends beyond classical DC to include marrow failure that does not respond to immunosuppression, idiopathic pulmonary fibrosis, and possibly other syndromes. We suggest that such patients be categorized as having an inherited disorder of telomere biology. Longitudinal studies of patients with very short telomeres but without classical DC are necessary to further understand the long-term sequelae, such as malignancy, osteonecrosis/osteoporosis, and pulmonary and liver disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.