ReviewMolecular pharmaceutics
Cell signaling and nuclear receptors: new opportunities for molecular pharmaceuticals in liver disease.
Review in Molecular pharmaceutics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- The Proposal of Molecular Mechanisms of Weak Organic Acids Intake-Induced Improvement of Insulin Resistance in Diabetes Mellitus via Elevation of Interstitial Fluid pH.International journal of molecular sciences · 2018Review
- Role of c-Jun-N-Terminal Kinase in Pregnane X Receptor-Mediated Induction of Human Cytochrome P4503A4 In Vitro.Drug metabolism and disposition: the biological fate of chemicals · 2018Article
- High glucose upregulates BACE1-mediated Aβ production through ROS-dependent HIF-1α and LXRα/ABCA1-regulated lipid raft reorganization in SK-N-MC cells.Scientific reports · 2016Article
- A SUMO-acetyl switch in PXR biology.Biochimica et biophysica acta · 2016Article
- Serine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivo.Biochemical pharmacology · 2015Article
- Expression profiles uncover the relationship between erythropoietin and cell proliferation in rat hepatocytes after a partial hepatectomy.Cellular & molecular biology letters · 2014Article
- Post-translational and post-transcriptional modifications of pregnane X receptor (PXR) in regulation of the cytochrome P450 superfamily.Current drug metabolism · 2013Review
- Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers.Brain : a journal of neurology · 2012Article
- Gold nanoparticles functionalized with peptides for specific affinity aggregation assays of estrogen receptors and their agonists.Sensors (Basel, Switzerland) · 2012Article
- Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters.Life sciences · 2011Article
- Post-translational modification of pregnane x receptor.Pharmacological research · 2011Review
- Zinc and alcoholic liver disease.Digestive diseases (Basel, Switzerland) · 2010Review
- PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- A systematic analysis of predicted phosphorylation sites within the human pregnane X receptor protein.The Journal of pharmacology and experimental therapeutics · 2009Article
- Bile acids as regulatory molecules.Journal of lipid research · 2009Review
- Article
- Cyclic AMP-dependent protein kinase signaling modulates pregnane x receptor activity in a species-specific manner.The Journal of biological chemistry · 2009Article
- Possible regulation of genes associated with intracellular signaling cascade in rat liver regeneration.Scandinavian journal of gastroenterology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Liver-enriched nuclear receptors (NRs) collectively function as metabolic and toxicological "sensors" that mediate liver-specific gene-activation in mammals. NR-mediated gene-environment interaction regulates important steps in the hepatic uptake, metabolism, and excretion of glucose, fatty acids, lipoproteins, cholesterol, bile acids, and xenobiotics. Hence, liver-enriched NRs play pivotal roles in the overall control of energy homeostasis in mammals. While it is well-recognized that ligand-binding is the primary mechanism behind activation of NRs, recent research reveals that multiple signal transduction pathways modulate NR-function in liver. The interface between specific signal transduction pathways and NRs helps to determine their overall responsiveness to various environmental and physiological stimuli. In general, phosphorylation of hepatic NRs regulates multiple biological parameters including their transactivation capacity, DNA binding, subcellular location, capacity to interact with protein-cofactors, and protein stability. Certain pathological conditions including inflammation, morbid obesity, hyperlipidemia, atherosclerosis, insulin resistance, and type-2 diabetes are known to modulate selected signal transduction pathways in liver. This review will focus upon recent insights regarding the molecular mechanisms that comprise the interface between disease-mediated activation of hepatic signal transduction pathways and liver-enriched NRs. This review will also highlight the exciting opportunities presented by this new knowledge to develop novel molecular and pharmaceutical strategies for combating these increasingly prevalent human diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.