ArticleThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale2005
The laboratory diagnosis of hepatitis B virus.
Article in The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Hepatitis B in Ghana: a systematic review & meta-analysis of prevalence studies (1995-2015).BMC infectious diseases · 2016Pooled it
- Prevalence of HIV and hepatitis B coinfection in Ghana: a systematic review and meta-analysis.AIDS research and therapy · 2016Pooled it
- HBV Serologic Testing Practices and Reactivation Outcomes Before Rituximab Initiation: A Retrospective Observational Study at an Academic Tertiary Care Centre.Journal of clinical medicine · 2026Article
- Sero-prevalence of hepatitis b virus infection and its associated factors among pregnant women attending antenatal care at public health facilities in Babile district, Eastern Ethiopia.BMC pregnancy and childbirth · 2025Article
- Hepatitis B virus quantitative surface antigen levels differ by genotype.Canadian liver journal · 2025Article
- A New Approach in the Early Electrochemical Diagnosis of Hepatitis B Virus Infection using Carbon-based Nanomaterials.Recent patents on nanotechnology · 2025Review
- Hepatitis B infection (HBsAg and HBeAg) status among women attending antenatal care at public healthcare facilities of South Africa, 2017.PLOS global public health · 2025Article
- Chronic hepatitis B virus infection in Eastern Ethiopia: Clinical characteristics and determinants of cirrhosis.World journal of hepatology · 2024Article
- Good Practices and Initiatives for the Control and Elimination of Hepatitis B in the World: A Scoping Review.Cureus · 2024Article
- Diagnostic precision of Truenat® technique and co-relation of ALT levels with HBV-DNA viral load among HBsAg positive patients at a tertiary care hospital in Eastern Uttar Pradesh.Iranian journal of microbiology · 2024Article
- Prevalence of Hepatitis B in Canadian First-Time Blood Donors: Association with Social Determinants of Health.Viruses · 2024Article
- Effect of hepatitis B vaccination on HBV-infection among school children in Yaounde; ten years after the introduction of HBV vaccine into routine Immunization Program in Cameroon.The Pan African medical journal · 2024Article
- Protection level of anti-hepatitis B vaccine and immunoglobulin in a pediatric Cameroonian population.Journal of public health in Africa · 2023Article
- Article
- Prevalence of hepatitis B infection in the Gambian population: A narrative review of recent developments.Preventive medicine reports · 2023Review
- Development and characterization of a chronic hepatitis B murine model with a mutation in the START codon of an HBV polymerase.Physiological research · 2023Article
- Risk Factors for Hepatitis B Virus Infection in North Ethiopia: A Case-Control Study.Hepatic medicine : evidence and research · 2023Article
- Hepatitis B infection status among South Africans attending public health facilities over a five-year period: 2015 to 2019.PLOS global public health · 2023Article
- Prevalence of blood-borne viruses and hepatitis B vaccination status among haemodialysis patients in Central Australia.IJID regions · 2022Article
- Recombinase amplified CRISPR enhanced chain reaction (RACECAR) for viral genome detection.Nanoscale · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis B virus (HBV) chronically infects approximately 250,000 Canadians and 350 million people worldwide. Without intervention, approximately 15% to 40% of chronically infected individuals will eventually develop cirrhosis, end-stage liver disease or hepatocellular carcinoma, or require liver transplantation. The availability and extensive use of the HBV vaccine has dramatically reduced the number of incident infections in Canada and worldwide. Effective therapeutic agents have been and continue to be developed to treat chronic infection. The present review provides a comprehensive overview of diagnostic tests for HBV infection and immunity, and elaborates on HBV risk factors, vaccine prevention and therapeutic monitoring. HBV diagnosis is accomplished by testing for a series of serological markers of HBV and by additional testing to exclude alternative etiological agents such as hepatitis A and C viruses. Serological tests are used to distinguish acute, self-limited infections from chronic HBV infections and to monitor vaccine-induced immunity. Nucleic acid testing for HBV-DNA is increasingly being used to quantify HBV viral load and measure the effectiveness of therapeutic agents. Given the multitude of available tests and the complexity of clinical management, there is a critical need for greater coordination among clinicians, diagnostic laboratory personnel and researchers to define optimal laboratory diagnostic and monitoring assays so that the appropriate tests are used to maximize prevention and optimize treatment outcomes.
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