ArticlePloS one2007
Neuregulin-1 regulates cell adhesion via an ErbB2/phosphoinositide-3 kinase/Akt-dependent pathway: potential implications for schizophrenia and cancer.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 63 citations in OpenAlex.
- Fibroblast-derived EGF ligand neuregulin 1 induces fetal-like reprogramming of the intestinal epithelium without supporting tumorigenic growth.Disease models & mechanisms · 2023Article
- Neurodevelopmental signatures of narcotic and neuropsychiatric risk factors in 3D human-derived forebrain organoids.Molecular psychiatry · 2021Article
- Altered hippocampal gene expression and structure in transgenic mice overexpressing neuregulin 1 (Nrg1) type I.Translational psychiatry · 2018Article
- Neuregulin1-β decreases IL-1β-induced neutrophil adhesion to human brain microvascular endothelial cells.Translational stroke research · 2015Article
- Neuregulin 1-induced AKT and ERK phosphorylation in patients with fragile X syndrome (FXS) and intellectual disability associated with obstetric complications.Journal of molecular neuroscience : MN · 2014Article
- Global signaling effects of a schizophrenia-associated missense mutation in neuregulin 1: an exploratory study using whole genome and novel kinome approaches.Journal of neural transmission (Vienna, Austria : 1996) · 2014Article
- Article
- Investigation of gene effects and epistatic interactions between Akt1 and neuregulin 1 in the regulation of behavioral phenotypes and social functions in genetic mouse models of schizophrenia.Frontiers in behavioral neuroscience · 2014Article
- Transcriptome alterations of mitochondrial and coagulation function in schizophrenia by cortical sequencing analysis.BMC genomics · 2014Article
- Inverse cancer comorbidity: a serendipitous opportunity to gain insight into CNS disorders.Nature reviews. Neuroscience · 2013Review
- Integrative mechanisms of oriented neuronal migration in the developing brain.Annual review of cell and developmental biology · 2013Review
- Activated PTHLH coupling feedback phosphoinositide to G-protein receptor signal-induced cell adhesion network in human hepatocellular carcinoma by systems-theoretic analysis.TheScientificWorldJournal · 2012Article
- Abnormal cell properties and down-regulated FAK-Src complex signaling in B lymphoblasts of autistic subjects.The American journal of pathology · 2011Article
- Heregulin β-1 induces loss of cell-cell contact and enhances expression of MUC1 at the cell surface in HCC2998 and MKN45-1 cells.PloS one · 2011Article
- Beyond cAMP: The Regulation of Akt and GSK3 by Dopamine Receptors.Frontiers in molecular neuroscience · 2011Article
- The relationship among neuregulin 1-stimulated phosphorylation of AKT, psychosis proneness, and habituation of arousal in nonclinical individuals.Schizophrenia bulletin · 2011Article
- Identification of blood biomarkers for psychosis using convergent functional genomics.Molecular psychiatry · 2011Article
- In vivo and in vitro genetic evidence of involvement of neuregulin 1 in immune system dysregulation.Journal of molecular medicine (Berlin, Germany) · 2010Article
- Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice.PLoS biology · 2010Article
- Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models.PloS one · 2010Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundNeuregulin-1 (NRG1) is a putative schizophrenia susceptibility gene involved extensively in central nervous system development as well as cancer invasion and metastasis. Using a B lymphoblast cell model, we previously demonstrated impairment in NRG1alpha-mediated migration in cells derived from patients with schizophrenia as well as effects of risk alleles in NRG1 and catechol-O-methyltransferase (COMT), a second gene implicated both in schizophrenia susceptibility and in cancer. METHODOLOGY/PRINCIPAL
findingsHere, we examine cell adhesion, an essential component process of cell motility, using an integrin-mediated cell adhesion assay based on an interaction between ICAM-1 and the CD11a/CD18 integrin heterodimer expressed on lymphoblasts. In our assay, NRG1alpha induces lymphoblasts to assume varying levels of adhesion characterized by time-dependent fluctuations in the firmness of attachment. The maximum range of variation in adhesion over sixty minutes correlates strongly with NRG1alpha-induced migration (r(2) = 0.61). NRG1alpha-induced adhesion variation is blocked by erbB2, PI3K, and Akt inhibitors, but not by PLC, ROCK, MLCK, or MEK inhibitors, implicating the erbB2/PI3K/Akt1 signaling pathway in NRG1-stimulated, integrin-mediated cell adhesion. In cell lines from 20 patients with schizophrenia and 20 normal controls, cells from patients show a significant deficiency in the range of NRG1alpha-induced adhesion (p = 0.0002). In contrast, the response of patient-derived cells to phorbol myristate acetate is unimpaired. The COMT Val108/158Met genotype demonstrates a strong trend towards predicting the range of the NRG1alpha-induced adhesion response with risk homozygotes having decreased variation in cell adhesion even in normal subjects (p = 0.063). CONCLUSION/SIGNIFICANCE: Our findings suggest that a mechanism of the NRG1 genetic association with schizophrenia may involve the molecular biology of cell adhesion.
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