Trial reportPloS one2007
High uptake of exclusive breastfeeding and reduced early post-natal HIV transmission.
Trial report in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00310726 (Short Duration Exclusive Breastfeeding With Abrupt Weaning to Reduce the Risk of Mother-to-Child HIV Transmission), which is not on this map. Cited by 58 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Short Duration Exclusive Breastfeeding With Abrupt Weaning to Reduce the Risk of Mother-to-Child HIV Transmission
Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Antiretroviral interventions for preventing breast milk transmission of HIV.The Cochrane database of systematic reviews · 2014Pooled it
- A Protocol for a Cluster Randomized Trial on the Effect of a "feeding buddy" Program on adherence to the Prevention of Mother-To-Child-Transmission Guidelines in a Rural Area of KwaZulu-Natal, South Africa.Journal of acquired immune deficiency syndromes (1999) · 2016Trial
- Infant feeding practices were not associated with breast milk HIV-1 RNA levels in a randomized clinical trial in Botswana.AIDS and behavior · 2012Trial
- Valacyclovir suppressive therapy reduces plasma and breast milk HIV-1 RNA levels during pregnancy and postpartum: a randomized trial.The Journal of infectious diseases · 2012Trial
- Exclusive breastfeeding, maternal HIV disease, and the risk of clinical breast pathology in HIV-infected, breastfeeding women.American journal of obstetrics and gynecology · 2011Trial
- Early weaning increases diarrhea morbidity and mortality among uninfected children born to HIV-infected mothers in Zambia.The Journal of infectious diseases · 2011Trial
- Growth faltering due to breastfeeding cessation in uninfected children born to HIV-infected mothers in Zambia.The American journal of clinical nutrition · 2009Trial
- Infant feeding decisions among people living with human immunodeficiency virus in the United States: a pilot study.Frontiers in reproductive health · 2026Article
- Understanding practices of lactation and infant feeding together with women with HIV: the UPLIFT observational study protocol.Frontiers in reproductive health · 2026Article
- Human Immunodeficiency Virus and Breastfeeding: Clinical Considerations and Mechanisms of Transmission in the Modern Era of Combined Antiretroviral Therapy.Clinics in perinatology · 2024Review
- Breastfeeding in the United States Among Women With HIV: Con Viewpoint.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Review
- Localization of infection in neonatal rhesus macaques after oral viral challenge.PLoS pathogens · 2021Article
- Understanding Viral and Immune Interplay During Vertical Transmission of HIV: Implications for Cure.Frontiers in immunology · 2021Review
- Determinants of Adherence to National Infant Feeding Guidelines by Black Mothers Living with HIV.Ethnicity & disease · 2021Article
- Breastfeeding Practices Among Women Living with HIV in KwaZulu-Natal, South Africa: An Observational Study.Maternal and child health journal · 2020Observational
- HIV-Infected Mothers Who Decide to Breastfeed Their Infants Under Close Supervision in Belgium: About Two Cases.Frontiers in pediatrics · 2020Article
- Female Sex Workers' Experiences Selling Sex during Pregnancy and Post-Delivery in South Africa.Studies in family planning · 2019Article
- "In the United States, we say, 'No breastfeeding,' but that is no longer realistic": provider perspectives towards infant feeding among women living with HIV in the United States.Journal of the International AIDS Society · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundEmpirical data showing the clear benefits of exclusive breastfeeding (EBF) for HIV prevention are needed to encourage implementation of lactation support programs for HIV-infected women in low resource settings among whom replacement feeding is unsafe. We conducted a prospective, observational study in Lusaka, Zambia, to test the hypothesis that EBF is associated with a lower risk of postnatal HIV transmission than non-EBF. METHODS AND
resultsAs part of a randomized trial of early weaning, 958 HIV-infected women and their infants were recruited and all were encouraged to breastfeed exclusively to 4 months. Single-dose nevirapine was provided to prevent transmission. Regular samples were collected from infants to 24 months of age and tested by PCR. Detailed measurements of actual feeding behaviors were collected to examine, in an observational analysis, associations between feeding practices and postnatal HIV transmission. Uptake of EBF was high with 84% of women reporting only EBF cumulatively to 4 months. Post-natal HIV transmission before 4 months was significantly lower (p = 0.004) among EBF (0.040 95% CI: 0.024-0.055) than non-EBF infants (0.102 95% CI: 0.047-0.157); time-dependent Relative Hazard (RH) of transmission due to non-EBF = 3.48 (95% CI: 1.71-7.08). There were no significant differences in the severity of disease between EBF and non-EBF mothers and the association remained significant (RH = 2.68 95% CI: 1.28-5.62) after adjusting for maternal CD4 count, plasma viral load, syphilis screening results and low birth weight.
conclusionsNon-EBF more than doubles the risk of early postnatal HIV transmission. Programs to support EBF should be expanded universally in low resource settings. EBF is an affordable, feasible, acceptable, safe and sustainable practice that also reduces HIV transmission providing HIV-infected women with a means to protect their children's lives.
trial registrationClinicalTrials.gov NCT00310726.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.