ArticlePloS one2007
An animal model of emotional blunting in schizophrenia.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Aberrant Fear: Biological Underpinnings Relevant to Psychosis, Antipsychotic Drugs, and Psychotherapeutic Treatments, a Translational Approach.International journal of molecular sciences · 2026Review
- The importance of a multidimensional approach to the preclinical study of major depressive disorder and apathy.Emerging topics in life sciences · 2022Article
- Interneuron Heterotopia in the Lis1 Mutant Mouse Cortex Underlies a Structural and Functional Schizophrenia-Like Phenotype.Frontiers in cell and developmental biology · 2021Article
- Prediction of individual differences in fear response by novelty seeking, and disruption of contextual fear memory reconsolidation by ketamine.Neuropharmacology · 2016Article
- Deletion of Rapgef6, a candidate schizophrenia susceptibility gene, disrupts amygdala function in mice.Translational psychiatry · 2015Article
- Testing synaptic plasticity in dynamic mate choice decisions: N-methyl D-aspartate receptor blockade disrupts female preference.Proceedings. Biological sciences · 2014Article
- Evaluation of emotional blunting in behavioral variant frontotemporal dementia compared to Alzheimer's disease.Dementia and geriatric cognitive disorders · 2014Article
- Deletion of glutamate delta-1 receptor in mouse leads to enhanced working memory and deficit in fear conditioning.PloS one · 2013Article
- Deficits in emotional learning and memory in an animal model of schizophrenia.Behavioural brain research · 2012Article
- Behavioral analysis of NR2C knockout mouse reveals deficit in acquisition of conditioned fear and working memory.Neurobiology of learning and memory · 2011Article
- Mutant mouse models: genotype-phenotype relationships to negative symptoms in schizophrenia.Schizophrenia bulletin · 2010Article
- Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentials.Neurobiology of disease · 2009Article
- CNTRICS final task selection: social cognitive and affective neuroscience-based measures.Schizophrenia bulletin · 2009Review
- The social-emotional processing stream: five core constructs and their translational potential for schizophrenia and beyond.Biological psychiatry · 2008Article
- Evidence for deficits in behavioural and physiological responses in aged mice relevant to the psychiatric symptom of apathy.Brain and neuroscience advancesArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia is often associated with emotional blunting--the diminished ability to respond to emotionally salient stimuli--particularly those stimuli representative of negative emotional states, such as fear. This disturbance may stem from dysfunction of the amygdala, a brain region involved in fear processing. The present article describes a novel animal model of emotional blunting in schizophrenia. This model involves interfering with normal fear processing (classical conditioning) in rats by means of acute ketamine administration. We confirm, in a series of experiments comprised of cFos staining, behavioral analysis and neurochemical determinations, that ketamine interferes with the behavioral expression of fear and with normal fear processing in the amygdala and related brain regions. We further show that the atypical antipsychotic drug clozapine, but not the typical antipsychotic haloperidol nor an experimental glutamate receptor 2/3 agonist, inhibits ketamine's effects and retains normal fear processing in the amygdala at a neurochemical level, despite the observation that fear-related behavior is still inhibited due to ketamine administration. Our results suggest that the relative resistance of emotional blunting to drug treatment may be partially due to an inability of conventional therapies to target the multiple anatomical and functional brain systems involved in emotional processing. A conceptual model reconciling our findings in terms of neurochemistry and behavior is postulated and discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.