ArticlePloS one2007
Involvement of skeletal muscle gene regulatory network in susceptibility to wound infection following trauma.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Drosophila melanogaster as a model host for studying Pseudomonas aeruginosa feeding infection.Nature protocols · 2026Review
- Intelectin 3 is dispensable for resistance against a mycobacterial infection in zebrafish (Danio rerio).Scientific reports · 2019Article
- Options and Limitations in Clinical Investigation of Bacterial Biofilms.Clinical microbiology reviews · 2018Review
- Interplay between trauma and Pseudomonas entomophila infection in flies: a central role of the JNK pathway and of CrebA.Scientific reports · 2017Article
- Muscles provide protection during microbial infection by activating innate immune response pathways in Drosophila and zebrafish.Disease models & mechanisms · 2016Article
- Overexpression of Latent TGFβ Binding Protein 4 in Muscle Ameliorates Muscular Dystrophy through Myostatin and TGFβ.PLoS genetics · 2016Article
- The importance of the Pseudomonas aeruginosa type III secretion system in epithelium traversal depends upon conditions of host susceptibility.Infection and immunity · 2015Article
- Defining the microbial effluxome in the content of the host-microbiome interaction.Frontiers in pharmacology · 2015Article
- Thorax injury lowers resistance to infection in Drosophila melanogaster.Infection and immunity · 2014Article
- Human pathogenic bacteria, fungi, and viruses in Drosophila: disease modeling, lessons, and shortcomings.Virulence · 2014Review
- Drosophila melanogaster: a first step and a stepping-stone to anti-infectives.Current opinion in pharmacology · 2013Review
- Microbial efflux systems and inhibitors: approaches to drug discovery and the challenge of clinical implementation.The open microbiology journal · 2013Article
- Drosophila immune priming against Pseudomonas aeruginosa is short-lasting and depends on cellular and humoral immunity.F1000Research · 2013Article
- Down-regulation of glutatione S-transferase α 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Recent Advances in the Use of Drosophila melanogaster as a Model to Study Immunopathogenesis of Medically Important Filamentous Fungi.International journal of microbiology · 2012Article
- Concepts and principles of photodynamic therapy as an alternative antifungal discovery platform.Frontiers in microbiology · 2012Article
- The Drosophila melanogaster host model.Journal of oral microbiology · 2012Article
- Article
- SMAD signaling drives heart and muscle dysfunction in a Drosophila model of muscular dystrophy.Human molecular genetics · 2011Article
- Drosophila melanogaster as a model for human intestinal infection and pathology.Disease models & mechanisms · 2011Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Despite recent advances in our understanding the pathophysiology of trauma, the basis of the predisposition of trauma patients to infection remains unclear. A Drosophila melanogaster/Pseudomonas aeruginosa injury and infection model was used to identify host genetic components that contribute to the hyper-susceptibility to infection that follows severe trauma. We show that P. aeruginosa compromises skeletal muscle gene (SMG) expression at the injury site to promote infection. We demonstrate that activation of SMG structural components is under the control of cJun-N-terminal Kinase (JNK) Kinase, Hemipterous (Hep), and activation of this pathway promotes local resistance to P. aeruginosa in flies and mice. Our study links SMG expression and function to increased susceptibility to infection, and suggests that P. aeruginosa affects SMG homeostasis locally by restricting SMG expression in injured skeletal muscle tissue. Local potentiation of these host responses, and/or inhibition of their suppression by virulent P. aeruginosa cells, could lead to novel therapies that prevent or treat deleterious and potentially fatal infections in severely injured individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.