ArticlePloS one2007
The oral cavity and age: a site of chronic inflammation?
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Association between dental caries and self-reported COPD prevalence in U.S. adults ages ≥ 60-year: a cross-sectional analysis of NHANES 2015-2020.Journal of oral microbiology · 2026Article
- Association of periodontitis and tooth loss with extent of coronary atherosclerosis in patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2023Article
- Prostanoid Metabolites as Biomarkers in Human Disease.Metabolites · 2022Review
- Exploratory studies of oral and fecal microbiome in healthy human aging.Frontiers in aging · 2022Article
- Systemic Sclerosis: Elevated Levels of Leukotrienes in Saliva and Plasma Are Associated with Vascular Manifestations and Nailfold Capillaroscopic Abnormalities.International journal of environmental research and public health · 2021Article
- Recent Insights Into the Prognostic and Therapeutic Applications of Lysozymes.Frontiers in pharmacology · 2021Review
- Acetaminophen influences social and economic trust.Scientific reports · 2019Article
- Differential Associations for Salivary Sodium, Potassium, Calcium, and Phosphate Levels with Carotid Intima Media Thickness, Heart Rate, and Arterial Stiffness.Disease markers · 2018Article
- Article
- Review
- Inflammatory mediators in saliva associated with arterial stiffness and subclinical atherosclerosis.Journal of hypertension · 2013Article
- Leukotrienes as modifiers of preclinical atherosclerosis?TheScientificWorldJournal · 2012Review
- Apoptotic genes are differentially expressed in aged gingival tissue.Journal of dental research · 2011Article
- Leukotriene signaling in atherosclerosis and ischemia.Cardiovascular drugs and therapy · 2009Review
- Inflammatory signaling through leukotriene receptors in atherosclerosis.Current atherosclerosis reports · 2008Review
- Age- and Periodontal Disease Independent Correlation of Salivary Amino Acids.In vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAging may be accompanied by a low grade chronic up-regulation of inflammatory mediators. A variety of endogenous locally released mediators as well as inflammatory cells have been reported in the human oral cavity. The aim of this investigation was to determine the presence of different classes of inflammatory mediators in human saliva and correlate the levels with age. METHODOLOGY AND PRINCIPAL
findingsUnstimulated whole buccal salivary samples were obtained in the morning from 94 healthy volunteers within 30 minutes after waking. None of the participants had taken aspirin in the week prior to the saliva collection. Lysozyme activity, eicosanoid levels (prostaglandin E(2) and leukotriene B(4)) and MMP-9 activity were measured. The antimicrobial activity (lysozyme activity) was not correlated with age whereas PGE(2) levels were markedly correlated with age (r = 0.29; P<0.05; n = 56). Saliva from healthy subjects (< or =40 years) compared with data derived from older volunteers (>40 years) demonstrated a significant increase in the mean values for PGE(2) and MMP-9 activity with age. In addition, significant correlations were observed between LTB(4) and PGE(2) (r = 0.28; P<0.05; n = 56) and between LTB(4) levels and MMP-9 activity in smokers (r = 0.78; P<0.001; n = 15). CONCLUSIONS/SIGNIFICANCE: The presence of significant levels and activity of inflammatory mediators in saliva suggests that the oral cavity of healthy subjects may be in a constant low state of inflammation associated with age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.