ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2007
Clinical course of high-grade glioma patients with a "biopsy-only" surgical approach: a need for individualised treatment.
Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of overall survival and postoperative neurologic deficits after resection or biopsy of butterfly glioblastoma.Neurosurgical review · 2022Pooled it
- Sunitinib administered prior to radiotherapy in patients with non-resectable glioblastoma: results of a phase II study.Targeted oncology · 2014Trial
- Butterfly gliomas: to biopsy or to ablate - a longitudinal cohort study.Journal of neuro-oncology · 2026Article
- Factors associated with poor prognosis in elderly biopsy-only glioblastoma patients.Acta neurochirurgica · 2025Article
- Diffusion changes in minimally invasive parafascicular approach for deep-seated tumours: impact on clinical outcomes.Neurosurgical review · 2025Article
- Defining the impact of adjuvant treatment on the prognosis of patients with inoperable glioblastoma undergoing biopsy only: does the survival benefit outweigh the treatment effort?Neurosurgical review · 2022Article
- Surgery vs. Biopsy in the Treatment of Butterfly Glioblastoma: A Systematic Review and Meta-Analysis.Cancers · 2022Review
- Resection versus biopsy in the treatment of multifocal glioblastoma: a weighted survival analysis.Journal of neuro-oncology · 2020Article
- Autoantibody Profiling of Glioma Serum Samples to Identify Biomarkers Using Human Proteome Arrays.Scientific reports · 2015Article
- The butterfly effect on glioblastoma: is volumetric extent of resection more effective than biopsy for these tumors?Journal of neuro-oncology · 2014Article
- Tumour and serum MGMT promoter methylation and protein expression in glioblastoma patients.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2011Article
- Glioblastoma: changing expectations?Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2011Review
- Efficacy of laser interstitial thermal therapy (LITT) for newly diagnosed and recurrentNeuro-oncology advancesArticle
- Radiological, clinical, and molecular analyses reveal distinct subtypes of butterfly glioblastomas affecting the prognosis.Neuro-oncology advancesArticle
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9 authors.
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Abstract
introduction'Biopsy-only' high-grade glioma (HGG) patients get limited benefit from post-operative treatments, and as a group, negatively impact median survival outcomes. MATERIAL AND
methodsWe retrospectively evaluated clinical characteristics, treatment and overall survival of HGG patients with a 'biopsy- only' surgical approach diagnosed between 1997 and 2005 at a University Hospital in Spain.
resultsIn 31% of 294 suspected gliomas, only a diagnostic biopsy was undertaken. Reasons for 'biopsy-only' for all patients were either location in eloquent areas: (motor area 18.7%, language area 25,3%, basal ganglia 7.7%, visual area 4.4%) or extension of the disease (corpus callosum invasion 14.3% and multicentricity/multifocality 28.6%). Seventy-four patients (80.4%) were HGG: 26% of all grade IV and 49% of all grade III tumours. For these patients, post-operative Karnofsky Performance Status of over 70%, median age and median survival were, respectively: 64 and 70%, 60.7 and 57 years old, and 23.1 and 42.7 weeks (p=0.0006). Patients lived longer if post-operative treatment was given, in all grades (p<0.0001). Nineteen patients (25.6%) died within 42 days after surgery. Only 60% of them initiated radiotherapy and 10% of them did not complete it. However, tumour grade, radiotherapy and temozolomide- based chemotherapy were independently associated with longer survival in multivariate analysis (p<0.05).
conclusionAlmost one third of HGG patients can undergo only a biopsy and not debulking surgery. Although radiotherapy improves survival, only 50% of them complete the treatment. An individualised approach to these patients is needed to facilitate a correct analysis of therapy results. New therapies must be investigated in these patients.
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