ArticleThe international journal of cardiovascular imaging2008
Diagnostic accuracy of myocardial perfusion imaging with single photon emission computed tomography and positron emission tomography: a comparison with coronary angiography.
Article in The international journal of cardiovascular imaging, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 45 citations in OpenAlex.
- Impact of software tools and kinetic model selection on myocardial blood flow and flow reserve quantitation inJournal of applied clinical medical physics · 2026Article
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- Article
- Coronary CT angiography: Beyond morphological stenosis analysis.World journal of cardiology · 2013Review
- Biological characterization of F-18-labeled rhodamine B, a potential positron emission tomography perfusion tracer.Nuclear medicine and biology · 2013Article
- Use of coronary CT angiography in the diagnosis of patients with suspected coronary artery disease: findings and clinical indications.Journal of geriatric cardiology : JGC · 2012Article
- Quantitative cardiac positron emission tomography: the time is coming!Scientifica · 2012Review
- Multislice computed tomography angiography in the diagnosis of coronary artery disease.Journal of geriatric cardiology : JGC · 2011Article
- Diagnostic value of SPECT, PET and PET/CT in the diagnosis of coronary artery disease: A systematic review.Biomedical imaging and intervention journal · 2011Article
- Microvascular angina: assessment of coronary blood flow, flow reserve, and metabolism.Current cardiology reports · 2011Review
- Diagnosis and prognosis of coronary artery disease: PET is superior to SPECT: Pro.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2010Article
- Preoperative evaluation of patients with possible coronary artery disease.Current cardiology reports · 2010Review
- Diagnostic and clinical benefit of combined coronary calcium and perfusion assessment in patients undergoing PET/CT myocardial perfusion stress imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2010Article
- Defining noninvasive imaging strategies in coronary artery disease: Which patients require further evaluation after coronary angiography with multislice computed tomography?Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyReview
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to compare the diagnostic accuracy of myocardial perfusion imaging (MPI) by positron emission tomography (PET) with the diagnostic accuracy of MPI by single photon emission computed tomography (SPECT) in two comparable patient cohorts, using coronary angiography (CA) as the standard of reference.
methodsA "SPECT-group" of 80 patients (15 female, 65 male; mean age 60+/-9 years) and a "PET-group" of 70 patients (14 female, 56 male; mean age 57+/-10 years) underwent a one day stress/rest examination either with attenuation-corrected (13)N-ammonia PET or attenuation-corrected (201)TlCl SPECT or (99m)Tc-hexakis-methoxy-isobutyl-isonitril (MIBI) SPECT. PET and SPECT results were semiquantitatively graded using a 6-segment heart model. All patients underwent CA, and stenoses were graded as a diameter reduction >or=50%.
resultsCoronary findings between both groups did not significantly differ at CA. For the SPECT-group overall sensitivity and specificity for localisation of stenoses was 77% and 84%. Respective values for the PET-group were 97% and 84%. The specificity of MPI by SPECT in the detection of ischemia was 74% and 91% for MPI by PET. The diagnostic accuracy of MPI improves when the individual coronary dominance and previous coronary revascularisations are taken into account.
conclusionMPI by (13)N-ammonia PET is more sensitive in the detection and localisation of coronary stenoses, and more specific in the detection of ischemia than MPI by (201)TlCl/(99m)MIBI SPECT.
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