ArticlePathology oncology research : POR2007
Prognostic significance of loss of c-fos protein in gastric carcinoma.
Article in Pathology oncology research : POR, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- A deep learning method to integrate extracelluar miRNA with mRNA for cancer studies.Bioinformatics (Oxford, England) · 2024Article
- Identification of anti-gastric cancer effects and molecular mechanisms of resveratrol: From network pharmacology and bioinformatics to experimental validation.World journal of gastrointestinal oncology · 2024Article
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- An integrated analysis of prognostic mRNA signature in early- and progressive-stage gastric adenocarcinoma.Frontiers in molecular biosciences · 2022Article
- Selective antagonism of cJun for cancer therapy.Journal of experimental & clinical cancer research : CR · 2020Review
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- Bioinformatics analysis to identify action targets in NCI-N87 gastric cancer cells exposed to quercetin.Pharmaceutical biology · 2018Article
- Analysis of Transcription Factor-Related Regulatory Networks Based on Bioinformatics Analysis and Validation in Hepatocellular Carcinoma.BioMed research international · 2018Article
- c-Fos over-expression promotes radioresistance and predicts poor prognosis in malignant glioma.Oncotarget · 2016Article
- Article
- Expression of c-fos was associated with clinicopathologic characteristics and prognosis in pancreatic cancer.PloS one · 2015Article
- c-Jun promotes cell migration and drives expression of the motility factor ENPP2 in soft tissue sarcomas.The Journal of pathology · 2014Article
- Regression analysis of combined gene expression regulation in acute myeloid leukemia.PLoS computational biology · 2014Article
- c-FOS suppresses ovarian cancer progression by changing adhesion.British journal of cancer · 2014Article
- Identifying gastric cancer related genes using the shortest path algorithm and protein-protein interaction network.BioMed research international · 2014Article
- Knockdown of c-Fos suppresses the growth of human colon carcinoma cells in athymic mice.International journal of cancer · 2012Article
- Emerging roles of ATF2 and the dynamic AP1 network in cancer.Nature reviews. Cancer · 2010Review
- C-Fos expression is a molecular predictor of progression and survival in epithelial ovarian carcinoma.British journal of cancer · 2008Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
c-fos was first identified as a viral oncoprotein, and has been studied in terms of its oncogenic function in tumorigenesis. Many experimental and clinical data indicated that c-fos expression plays a role in the progression of several types of carcinomas. However, some recent studies challenge this view as they indicate that c-fos has tumor suppressor activity. In the present study, we assessed c-fos protein expression in 625 consecutive gastric cancers immunohistochemically, and analyzed its relationship with clinicopathologic factors and survival. We found that a loss of c-fos expression is correlated with a more advanced stage, lymph node metastasis, lymphatic invasion and shorter survival, indicating that c-fos expression in gastric cancer cells is lost during progression and that this loss is associated with a poor prognosis. The above findings suggest that loss of c-fos expression has tumor suppressor activity in gastric cancer and we suspect that this suppressor activity might be related to the pro-apoptotic function of c-fos.
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