ArticlePsychosomatic medicine2008
Childhood socioeconomic status and serotonin transporter gene polymorphism enhance cardiovascular reactivity to mental stress.
Article in Psychosomatic medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Socioeconomic Status and Cardiovascular Responses to Standardized Stressors: A Systematic Review and Meta-Analysis.Psychosomatic medicine · 2018Pooled it
- Effect of a simulated active commute to school on cardiovascular stress reactivity.Medicine and science in sports and exercise · 2010Trial
- Weaker Effects of Educational Attainment on Chronic Medical Conditions in American Indian Alaska Native, Black, and Latino Adults: National Health Interview Survey 2023.Open journal of medical sciences · 2025Article
- Cardiovascular reactivity, stress, and personal emotional salience: Choose your tasks carefully.Psychophysiology · 2022Article
- Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism interacts with gender to influence cortisol responses to mental stress.Psychoneuroendocrinology · 2017Article
- Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence.American heart journal · 2017Article
- 5-HTTLPR polymorphism is linked to neural mechanisms of selective attention in preschoolers from lower socioeconomic status backgrounds.Developmental cognitive neuroscience · 2016Article
- Childhood socioeconomic status and cardiovascular reactivity and recovery among Black and White men: Mitigating effects of psychological resources.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2016Article
- Differential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress Exposure.International journal of hypertension · 2012Article
- Effects of 5HTTLPR on cardiovascular response to an emotional stressor.Psychosomatic medicine · 2011Article
- A polymorphism in the serotonin transporter gene moderates cardiovascular reactivity to psychosocial stress.Psychosomatic medicine · 2011Article
- Early environment affects neuroendocrine regulation in adulthood.Social cognitive and affective neuroscience · 2011Article
- Low life course socioeconomic status (SES) is associated with negative NEO PI-R personality patterns.International journal of behavioral medicine · 2011Article
- Early life stress downregulates endothelin receptor expression and enhances acute stress-mediated blood pressure responses in adult rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
- Associations of depressive symptoms, trait hostility, and gender with C-reactive protein and interleukin-6 response after emotion recall.Psychosomatic medicine · 2010Article
- Socioeconomic status moderates associations between CNS serotonin and expression of beta2-integrins CD11b and CD11c.Journal of psychiatric research · 2010Article
- Association of adverse childhood environment and 5-HTTLPR Genotype with late-life depression.The Journal of clinical psychiatry · 2009Article
- Positive affect is associated with cardiovascular reactivity, norepinephrine level, and morning rise in salivary cortisol.Psychophysiology · 2009Article
- Prospects of psychosomatic medicine.BioPsychoSocial medicine · 2009Article
- How and why does the 5-HTTLPR gene moderate associations between maternal unresponsiveness and children's disruptive problems?Child developmentArticle
Corrections and comments
- Erratum issued
Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveTo test the hypothesis that low socioeconomic status (SES) and the 5HTTLPR L allele are associated with increased cardiovascular reactivity (CVR) to stress in a larger sample and that SES and 5HTTLPR genotypes interact to enhance CVR to stress. CVR to mental stress has been proposed as one mechanism linking stress to the pathogenesis of cardiovascular disease. The more transcriptionally efficient long (L) allele of a polymorphism of the serotonin transporter gene promoter (5HTTLPR) has been found associated with increased risk of myocardial infarction. We found the long allele associated with larger CVR to mental stress in a preliminary study of 54 normal volunteers.
methodsSubjects included 165 normal community volunteers stratified for race, gender, and SES, who underwent mental stress testing.
resultsChildhood SES as indexed by Father's Education Level was associated with larger systolic blood pressure (SBP) (p < .05) and diastolic blood pressure (DBP) (p = .01) responses to mental stress. The L allele was associated with larger SBP (p = .04), DBP (p < .0001), and heart rate (p = .04) responses to mental stress compared with the short (S) allele. Subjects with the SS genotype and high Father's Education exhibited smaller SBP (5.2 mm Hg) and DBP (2.9 mm Hg) responses than subjects with LL genotype and low Father's Education (SBP = 13.3 mm Hg, p = .002; DBP = 9.7 mm Hg, p < .0001).
conclusionsBoth the 5HTTLPR long allele and low SES, particularly during childhood, are associated with increased CVR to mental stress, which could account, at least in part, for the increased cardiovascular disease risk associated with these characteristics. If confirmed in further research, these characteristics could be used to identify persons who might benefit from preventive interventions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.