ArticleHypertension (Dallas, Tex. : 1979)2008
Endothelial dysfunction and the development of renal injury in spontaneously hypertensive rats fed a high-fat diet.
Article in Hypertension (Dallas, Tex. : 1979), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 113 citations in OpenAlex.
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- Unexpected consequences: Spontaneous kidney rupture following heavy lifting.Urology case reports · 2025Article
- Obesity and Metabolic Health in CKD.Clinical journal of the American Society of Nephrology : CJASN · 2025Review
- Podocyte-Specific Deletion of MCP-1 Fails to Protect against Angiotensin II- or Adriamycin-Induced Glomerular Disease.International journal of molecular sciences · 2024Article
- A prognostic nomogram for recurrence survival in post-surgical patients with varicose veins of the lower extremities.Scientific reports · 2024Article
- Body roundness index is related to the low estimated glomerular filtration rate in Chinese population: A cross-sectional study.Frontiers in endocrinology · 2023Article
- Dahl Salt-Resistant Rat Is Protected against Hypertension during Diet-Induced Obesity.Nutrients · 2022Article
- Increased Risk of Chronic Kidney Disease Associated With Weight Gain in Healthy Adults: Insight From Metabolic Profiles and Body Composition.Frontiers in medicine · 2021Article
- A "Western Diet" promotes symptoms of hepatic steatosis in spontaneously hypertensive rats.International journal of experimental pathology · 2020Article
- Tipping the scales: Are females more at risk for obesity- and high-fat diet-induced hypertension and vascular dysfunction?British journal of pharmacology · 2019Review
- Impact of obesity as an independent risk factor for the development of renal injury: implications from rat models of obesity.American journal of physiology. Renal physiology · 2019Review
- Early consumption of high-fat diet worsens renal damage in spontaneously hypertensive rats in adulthood.International journal of physiology, pathophysiology and pharmacology · 2019Article
- Naoxintong Capsule Inhibits the Development of Cardiovascular Pathological Changes in Bama Minipig Through Improving Gut Microbiota.Frontiers in pharmacology · 2019Article
- An experimental model for hypertensive crises emergencies: Long-term high-fat diet followed by acute vasoconstriction stress on spontaneously hypertensive rats.Experimental biology and medicine (Maywood, N.J.) · 2018Article
- Effect of prehypertensive losartan therapy on AT1R and ATRAP methylation of adipose tissue in the later life of high‑fat‑fed spontaneously hypertensive rats.Molecular medicine reports · 2018Article
- The complex effects of adipokines in the patients with kidney disease.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2018Review
- Visceral adiposity and renal function: an observational study from SPECT-China.Lipids in health and disease · 2017Observational
- Obesity and kidney disease: hidden consequences of the epidemic.Future science OA · 2017Review
- Obesity and Kidney Disease: Hidden Consequences of the Epidemic.Kidney diseases (Basel, Switzerland) · 2017Article
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
Obesity and hypertension have been identified as cardiovascular risk factors that contribute to the progression of end-stage renal disease. To examine the mechanisms by which a high-fat diet and hypertension contribute to endothelial dysfunction and renal injury, 8-week-old male spontaneously hypertensive rats and Wistar rats were fed a high-fat (36% fat) or a normal-fat (7% fat) diet for 10 weeks. The high-fat diet increased body weight in Wistar and hypertensive rats by 25 and 31 g, respectively. Systolic blood pressure was higher in the hypertensive rats compared with Wistar rats; however, blood pressure was unaltered by the high-fat diet. Afferent arteriole response to acetylcholine was impaired in the high-fat groups after just 3 weeks. Renal macrophage infiltration was increased in the hypertensive high-fat group compared with others, and monocyte chemoattractant protein-1 excretion was increased in both of the high-fat-fed groups. Renal PCR arrays displayed significant increases in 2 inflammatory genes in hypertensive rats fed a normal diet, 1 gene was increased in high-fat-fed Wistar rats, whereas 12 genes were increased in high-fat-fed hypertensive rats. Urinary albumin excretion was increased in the hypertensive rats compared with the Wistar rats, which was further exacerbated by the high-fat diet. Glomerular nephrin expression was reduced and desmin was increased by the high-fat diet in the hypertensive rats. Our results indicate that endothelial dysfunction precedes renal injury in normotensive and spontaneously hypertensive rats fed a high-fat diet, and hypertension with obesity induces a powerful inflammatory response and disruption of the renal filtration barrier.
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