Evidence map›Paper›PMID 18157899›Full record

ReviewBirth defects research. Part B, Developmental and reproductive toxicology2007

Molecular basis for skeletal variation: insights from developmental genetic studies in mice.

C Kappen, A Neubüser, R Balling, R Finnell

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Birth defects research. Part B, Developmental and reproductive toxicology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Folate modulates Hox gene-controlled skeletal phenotypes.Genesis (New York, N.Y. : 2000) · 2004
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

C KappenCenter for Human Molecular Genetics, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA. claudia.kappen@pbrc.edu
A Neubüser
R Balling
R Finnell
Helmholtz Centre for Infection Research · DENebraska Medical Center · USResearch Institute of Molecular Pathology · ATUniversity of Nebraska Medical Center · US

Funding

Genetic Dissection of Skeletal PatterningR21AR052731 · NIAMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KAPPEN, CLAUDIA T. · 2005 to 2006
$370k
FOLATE AND HOX GENES IN CRANIOFACIAL DEVELOPMENTR21DE014523 · NIDCR · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KAPPEN, CLAUDIA T. · 2002 to 2003
$294k
NIAMS NIH HHS R21 AR052731
6 · The paper itself

Abstract

Skeletal variations are common in humans, and potentially are caused by genetic as well as environmental factors. We here review molecular principles in skeletal development to develop a knowledge base of possible alterations that could explain variations in skeletal element number, shape or size. Environmental agents that induce variations, such as teratogens, likely interact with the molecular pathways that regulate skeletal development.

Indexed as

Abnormalities, Drug-InducedAnimalsBone and BonesBone DevelopmentGene Expression Regulation, DevelopmentalMiceTeratogensTeratogens

Identifiers

PMID18157899
PMCPMC3938168
OpenAlexW2166138519

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.