ArticleShock (Augusta, Ga.)2008
A mathematical simulation of the inflammatory response to anthrax infection.
Article in Shock (Augusta, Ga.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed.Vaccine · 2012Trial
- A mathematical model shows macrophages delay Staphylococcus aureus replication, but limitations in microbicidal capacity restrict bacterial clearance.Journal of theoretical biology · 2020Article
- A Bivalent Protein r-PAbxpB Comprising PA Domain IV and Exosporium Protein BxpB Confers Protection AgainstFrontiers in immunology · 2019Article
- Solving Immunology?Trends in immunology · 2017Review
- Deciphering the Counterplay of Aspergillus fumigatus Infection and Host Inflammation by Evolutionary Games on Graphs.Scientific reports · 2016Article
- Reverse Engineering the Inflammatory "Clock": From Computational Modeling to Rational Resetting.Drug discovery today. Disease models · 2016Article
- Inflammation Following Traumatic Brain Injury in Humans: Insights from Data-Driven and Mechanistic Models into Survival and Death.Frontiers in pharmacology · 2016Article
- Insights into the Role of Chemokines, Damage-Associated Molecular Patterns, and Lymphocyte-Derived Mediators from Computational Models of Trauma-Induced Inflammation.Antioxidants & redox signaling · 2015Review
- A Computational, Tissue-Realistic Model of Pressure Ulcer Formation in Individuals with Spinal Cord Injury.PLoS computational biology · 2015Article
- Computational modelling of the inflammatory response in trauma, sepsis and wound healing: implications for modelling resilience.Interface focus · 2014Review
- On the coupling of two models of the human immune response to an antigen.BioMed research international · 2014Article
- Sepsis: Something old, something new, and a systems view.Journal of critical care · 2012Article
- A low dimensional dynamical model of the initial pulmonary innate response to infection.Mathematical biosciences · 2012Article
- Sepsis: from pattern to mechanism and back.Critical reviews in biomedical engineering · 2012Review
- Inhalational anthrax (Ames aerosol) in naïve and vaccinated New Zealand rabbits: characterizing the spread of bacteria from lung deposition to bacteremia.Frontiers in cellular and infection microbiology · 2012Article
- Computational and systems biology in trauma and sepsis: current state and future perspectives.International journal of burns and trauma · 2012Article
- An agent-based model of inflammation and fibrosis following particulate exposure in the lung.Mathematical biosciences · 2011Article
- Modeling the host response to inhalation anthrax.Journal of theoretical biology · 2011Article
- In Silico Augmentation of the Drug Development Pipeline: Examples from the study of Acute Inflammation.Drug development research · 2011Article
- A systems model for immune cell interactions unravels the mechanism of inflammation in human skin.PLoS computational biology · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Bacillus anthracis (anthrax) can trigger an acute inflammatory response that results in multisystem organ failure and death. Previously, we developed a mathematical model of acute inflammation after gram-negative infection that had been matched qualitatively to literature data. We modified the properties of the invading bacteria in that model to those specific to B. anthracis and simulated the host response to anthrax infection. We simulated treatment strategies against anthrax in a genetically diverse population including the following: (1) antibiotic treatment initiated at various time points, (2) antiprotective antigen vaccine, and (3) a combination of antibiotics and vaccine. In agreement with studies in mice, our simulations showed that antibiotics only improve survival if administered early in the course of anthrax infection. Vaccination that leads to the formation of antibodies to protective antigen is anti-inflammatory and beneficial in averting shock and improving survival. However, antibodies to protective antigen alone are predicted not to be universally protective against anthrax infection. Rather, our simulations suggest that an optimal strategy would require both vaccination and antibiotic administration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.