ArticleEukaryotic cell2008
Genome-wide analysis of sterol-lipid storage and trafficking in Saccharomyces cerevisiae.
Article in Eukaryotic cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Insights intomSphere · 2026Article
- Target of Rapamycin Complex 1 (TORC1), Protein Kinase A (PKA) and Cytosolic pH Regulate a Transcriptional Circuit for Lipid Droplet Formation.International journal of molecular sciences · 2021Article
- Endoplasmic reticulum-plasma membrane contact sites integrate sterol and phospholipid regulation.PLoS biology · 2018Article
- Proper Sterol Distribution Is Required forG3 (Bethesda, Md.) · 2016Article
- Phosphatidylserine translocation at the yeast trans-Golgi network regulates protein sorting into exocytic vesicles.Molecular biology of the cell · 2015Article
- Deletion of murine Arv1 results in a lean phenotype with increased energy expenditure.Nutrition & diabetes · 2015Article
- Lipid droplet dynamics in budding yeast.Cellular and molecular life sciences : CMLS · 2015Review
- Regulation of lipid droplet dynamics in Saccharomyces cerevisiae depends on the Rab7-like Ypt7p, HOPS complex and V1-ATPase.Biology open · 2015Article
- A functional, genome-wide evaluation of liposensitive yeast identifies the "ARE2 required for viability" (ARV1) gene product as a major component of eukaryotic fatty acid resistance.The Journal of biological chemistry · 2014Article
- Lipid droplet formation on opposing sides of the endoplasmic reticulum.Journal of lipid research · 2012Review
- A detour for yeast oxysterol binding proteins.The Journal of biological chemistry · 2012Review
- Biogenesis and functions of lipid droplets in plants: Thematic Review Series: Lipid Droplet Synthesis and Metabolism: from Yeast to Man.Journal of lipid research · 2012Review
- Review
- Arv1 lipid transporter function is conserved between pathogenic and nonpathogenic fungi.Fungal genetics and biology : FG & B · 2012Article
- Distribution and functions of sterols and sphingolipids.Cold Spring Harbor perspectives in biology · 2011Review
- The putative lipid transporter, Arv1, is required for activating pheromone-induced MAP kinase signaling in Saccharomyces cerevisiae.Genetics · 2011Article
- Structural insights into triglyceride storage mediated by fat storage-inducing transmembrane (FIT) protein 2.PloS one · 2010Article
- Functional characterization and localization of Pneumocystis carinii lanosterol synthase.Eukaryotic cell · 2010Article
- Intracellular sterol dynamics.Biochimica et biophysica acta · 2009Review
- Linking phospholipid flippases to vesicle-mediated protein transport.Biochimica et biophysica acta · 2009Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pandemic of lipid-related disease necessitates a determination of how cholesterol and other lipids are transported and stored within cells. The first step in this determination is the identification of the genes involved in these transport and storage processes. Using genome-wide screens, we identified 56 yeast (Saccharomyces cerevisiae) genes involved in sterol-lipid biosynthesis, intracellular trafficking, and/or neutral-lipid storage. Direct biochemical and cytological examination of mutant cells revealed an unanticipated link between secretory protein glycosylation and triacylglycerol (TAG)/steryl ester (SE) synthesis for the storage of lipids. Together with the analysis of other deletion mutants, these results suggested at least two distinct events for the biogenesis of lipid storage particles: a step affecting neutral-lipid synthesis, generating the lipid core of storage particles, and another step for particle assembly. In addition to the lipid storage mutants, we identified mutations that affect the localization of unesterified sterols, which are normally concentrated in the plasma membrane. These findings implicated phospholipase C and the protein phosphatase Ptc1p in the regulation of sterol distribution within cells. This study identified novel sterol-related genes that define several distinct processes maintaining sterol homeostasis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.