ArticleJournal of bacteriology2008
Transcriptome analysis of sorbic acid-stressed Bacillus subtilis reveals a nutrient limitation response and indicates plasma membrane remodeling.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 67 citations in OpenAlex.
- Bacterial Volatile Organic Compounds Mediate a Cooperative Relationship Between Bacteria and Plants Under Heavy Metal Stress.Microbial biotechnology · 2026Article
- Insights into the utilisation of 1,2-propanediol and interactions with the cell envelope of Clostridium perfringens.Gut pathogens · 2025Article
- Alcohol-Based Chlorhexidine and Potassium Sorbate Rub Strengthens the Effectiveness of Traditional Hand Scrubbing and Improves Long-Lasting Effectiveness-Evaluation of Hand Preparation Protocols According to EN 12791.Antibiotics (Basel, Switzerland) · 2024Article
- Adaptation to sorbic acid in low sugar promotes resistance of yeast to the preservative.Heliyon · 2023Article
- Regulation of acetate tolerance by small ORF-encoded polypeptides modulating efflux pump specificity in Methylomonas sp. DH-1.Biotechnology for biofuels and bioproducts · 2023Article
- Nature-Identical Compounds and Organic Acids ReduceToxins · 2020Article
- SpoVG is Necessary for Sporulation inMicroorganisms · 2020Article
- Metabolic adaptability shifts of cell membrane fatty acids of Komagataeibacter hansenii HDM1-3 improve acid stress resistance and survival in acidic environments.Journal of industrial microbiology & biotechnology · 2019Article
- Short Chain Fatty Acid Biosynthesis in MicroalgaeMarine drugs · 2019Article
- A novel small RNA CoaR regulates coenzyme A biosynthesis and tolerance ofBiotechnology for biofuels · 2017Article
- Metabolic activity in dormant conidia of Aspergillus niger and developmental changes during conidial outgrowth.Fungal genetics and biology : FG & B · 2016Article
- Article
- Transcriptional Profiling Analysis of Bacillus subtilis in Response to High Levels of Fe(3.).Current microbiology · 2016Article
- Expanding the Limits of Thermoacidophily in the Archaeon Sulfolobus solfataricus by Adaptive Evolution.Applied and environmental microbiology · 2016Article
- RodZ and PgsA Play Intertwined Roles in Membrane Homeostasis ofFrontiers in microbiology · 2016Article
- Role of fatty acids in Bacillus environmental adaptation.Frontiers in microbiology · 2015Review
- Distinct effects of sorbic acid and acetic acid on the electrophysiology and metabolism of Bacillus subtilis.Applied and environmental microbiology · 2014Article
- Metabolic shift of Escherichia coli under salt stress in the presence of glycine betaine.Applied and environmental microbiology · 2014Article
- Acyl coenzyme A thioesterase 7 regulates neuronal fatty acid metabolism to prevent neurotoxicity.Molecular and cellular biology · 2013Article
- Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The weak organic acid sorbic acid is a commonly used food preservative, as it inhibits the growth of bacteria, yeasts, and molds. We have used genome-wide transcriptional profiling of Bacillus subtilis cells during mild sorbic acid stress to reveal the growth-inhibitory activity of this preservative and to identify potential resistance mechanisms. Our analysis demonstrated that sorbic acid-stressed cells induce responses normally seen upon nutrient limitation. This is indicated by the strong derepression of the CcpA, CodY, and Fur regulon and the induction of tricarboxylic acid cycle genes, SigL- and SigH-mediated genes, and the stringent response. Intriguingly, these conditions did not lead to the activation of sporulation, competence, or the general stress response. The fatty acid biosynthesis (fab) genes and BkdR-regulated genes are upregulated, which may indicate plasma membrane remodeling. This was further supported by the reduced sensitivity toward the fab inhibitor cerulenin upon sorbic acid stress. We are the first to present a comprehensive analysis of the transcriptional response of B. subtilis to sorbic acid stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.