ArticleThe Plant cell2007
3-hydroxy-3-methylglutaryl coenzyme a reductase 1 interacts with NORK and is crucial for nodulation in Medicago truncatula.
Article in The Plant cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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57 citing papers in PubMed, 187 citations in OpenAlex.
- Review
- A rare non-canonical splice site in Trema orientalis SYMRK does not affect its dual symbiotic functioning in endomycorrhiza and rhizobium nodulation.BMC plant biology · 2023Article
- GmBES1-1 dampens the activity of GmNSP1/2 to mediate brassinosteroid inhibition of nodulation in soybean.Plant communications · 2023Article
- 3-Hydroxy-3-methylglutaryl coenzyme A reductase genes from Glycine max regulate plant growth and isoprenoid biosynthesis.Scientific reports · 2023Article
- Dancing to a different tune, can we switch from chemical to biological nitrogen fixation for sustainable food security?PLoS biology · 2023Article
- Review
- Overexpression of Terpenoid Biosynthesis Genes Modifies Root Growth and Nodulation in Soybean (Cells · 2022Article
- Constitutive activation of a nuclear-localized calcium channel complex inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Innovation and appropriation in mycorrhizal and rhizobial Symbioses.The Plant cell · 2022Article
- Activation of the plant mevalonate pathway by extracellular ATP.Nature communications · 2022Article
- Calcium/calmodulin-mediated microbial symbiotic interactions in plants.Frontiers in plant science · 2022Review
- A Perspective on Developing a Plant 'Holobiont' for Future Saline Agriculture.Frontiers in microbiology · 2022Review
- Plant-specific histone deacetylases are essential for early and late stages of Medicago nodule development.Plant physiology · 2021Article
- Complexity of gene paralogues resolved in biosynthetic pathway of hepatoprotective iridoid glycosides in a medicinal herb, Picrorhiza kurroa through differential NGS transcriptomes.Molecular genetics and genomics : MGG · 2021Article
- Overexpression of Terpenoid Biosynthesis Genes From Garden Sage (Frontiers in plant science · 2021Article
- Calcium spikes, waves and oscillations in plant development and biotic interactions.Nature plants · 2020Review
- Receptor-Like Kinases Sustain Symbiotic Scrutiny.Plant physiology · 2020Review
- Celebrating 20 Years of Genetic Discoveries in Legume Nodulation and Symbiotic Nitrogen Fixation.The Plant cell · 2020Review
- Early Molecular Dialogue Between Legumes and Rhizobia: Why Are They So Important?Results and problems in cell differentiation · 2020Article
- TheFrontiers in plant science · 2020Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NORK in legumes encodes a receptor-like kinase that is required for Nod factor signaling and root nodule development. Using Medicago truncatula NORK as bait in a yeast two-hybrid assay, we identified 3-hydroxy-3-methylglutaryl CoA reductase 1 (Mt HMGR1) as a NORK interacting partner. HMGR1 belongs to a multigene family in M. truncatula, and different HMGR isoforms are key enzymes in the mevalonate biosynthetic pathway leading to the production of a diverse array of isoprenoid compounds. Testing other HMGR members revealed a specific interaction between NORK and HMGR1. Mutagenesis and deletion analysis showed that this interaction requires the cytosolic active kinase domain of NORK and the cytosolic catalytic domain of HMGR1. NORK homologs from Lotus japonicus and Sesbania rostrata also interacted with Mt HMGR1, but homologous nonsymbiotic kinases of M. truncatula did not. Pharmacological inhibition of HMGR activities decreased nodule number and delayed nodulation, supporting the importance of the mevalonate pathway in symbiotic development. Decreasing HMGR1 expression in M. truncatula transgenic roots by RNA interference led to a dramatic decrease in nodulation, confirming that HMGR1 is essential for nodule development. Recruitment of HMGR1 by NORK could be required for production of specific isoprenoid compounds, such as cytokinins, phytosteroids, or isoprenoid moieties involved in modification of signaling proteins.
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