ArticleJournal of hepatology2008
Small proline-rich proteins (SPRR) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT) in cholangiocytes.
Article in Journal of hepatology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- HLA-DQB1-mediated B cell-epithelial crosstalk drives EBV-associated inflammation in Hunner-type interstitial cystitis.Molecular therapy. Nucleic acids · 2025Article
- Article
- Analysis of Selected Small Proline-Rich Proteins in Tissue Homogenates from Samples of Head and Neck Squamous Cell Carcinoma.Diagnostics (Basel, Switzerland) · 2025Article
- Proteomic Modulation in TGF-β-Treated Cholangiocytes Induced by Curcumin Nanoparticles.International journal of molecular sciences · 2023Article
- Article
- Epigenetic Alterations of DNA Methylation and miRNA Contribution to Lung Adenocarcinoma.Frontiers in genetics · 2022Article
- Integration Analysis of m6A Related Genes in Skin Cutaneous Melanoma and the Biological Function Research of the SPRR1B.Frontiers in oncology · 2021Article
- Article
- Serum Small Proline-Rich Protein 2A (SPRR2A) Is a Noninvasive Biomarker in Gastric Cancer.Disease markers · 2020Article
- Small proline-rich protein 2B drives stress-dependent p53 degradation and fibroblast proliferation in heart failure.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- [Study on Genetype in Lung Squamous Carcinoma by High-throughput of Transcriptome Sequence].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2017Article
- Inhibitory effects ofMolecular vision · 2017Article
- SPRR2A expression in cholangiocarcinoma increases local tumor invasiveness but prevents metastasis.Clinical & experimental metastasis · 2013Article
- Small proline-rich repeat protein 3 enhances the sensitivity of esophageal cancer cells in response to DNA damage-induced apoptosis.Molecular oncology · 2013Article
- Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero.Developmental cell · 2012Article
- Advances in cholangiocyte immunobiology.American journal of physiology. Gastrointestinal and liver physiology · 2012Review
- SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity.BMC molecular biology · 2012Article
- Cooperation of p300 and PCAF in the control of microRNA 200c/141 transcription and epithelial characteristics.PloS one · 2012Article
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin increases the expression of genes in the human epidermal differentiation complex and accelerates epidermal barrier formation.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
- Skin cornification proteins provide global link between ROS detoxification and cell migration during wound healing.PloS one · 2010Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
BACKGROUND/
aimsDeficient biliary epithelial cell (BEC) expression of small proline-rich protein (SPRR) 2A in IL-6(-/-) mice is associated with defective biliary barrier function after bile duct ligation. And numerous gene array expression studies show SPRR2A to commonly be among the most highly up-regulated genes in many non-squamous, stressed and remodeling barrier epithelia. Since the function of SPRR in these circumstances is unknown, we tested the exploratory hypothesis that BEC SPRR2A expression contributes to BEC barrier function and wound repair.
methodsThe effect of SPRR2A expression was studied in primary mouse BEC cultures; in a BEC cell line after forced overexpression of SPRR2A; and in human livers removed at the time of liver transplantation.
resultsForced SPRR2A overexpression showed that it functions as a SH3 domain ligand that increases resistance to oxidative injury and promotes wound restitution by enhancing migration and acquisition of mesenchymal characteristics. Low confluency non-neoplastic mouse BEC cultures show a phenotype similar to the stable transfectants, as did spindle-shaped BEC participating in atypical ductular reactions in primary biliary cirrhosis.
conclusionsThese observations suggest that SPRR2A-related BEC barrier modifications represent a novel, but widely utilized and evolutionarily conserved, response to stress that is worthy of further study.
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Registered trials
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