ArticleJournal of chemical neuroanatomy2008
Dopamine binds to alpha(2)-adrenergic receptors in the song control system of zebra finches (Taeniopygia guttata).
Article in Journal of chemical neuroanatomy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Dopamine, Immunity, and Disease.Pharmacological reviews · 2023Review
- Serotonin receptors contribute to dopamine depression of lateral inhibition in the nucleus accumbens.Cell reports · 2022Article
- Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors.Translational psychiatry · 2021Article
- DeepCPI: A Deep Learning-based Framework for Large-scale in silico Drug Screening.Genomics, proteomics & bioinformatics · 2019Article
- Dopamine: Functions, Signaling, and Association with Neurological Diseases.Cellular and molecular neurobiology · 2019Review
- Dopamine and Noradrenaline in the Brain; Overlapping or Dissociate Functions?Frontiers in molecular neuroscience · 2019Article
- FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase.Nature communications · 2016Article
- Reduced vocal variability in a zebra finch model of dopamine depletion: implications for Parkinson disease.Physiological reports · 2015Article
- Dopamine physiology in the basal ganglia of male zebra finches during social stimulation.The European journal of neuroscience · 2015Article
- Quantification of [(11)C]yohimbine binding to α2 adrenoceptors in rat brain in vivo.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- Singing under the influence: examining the effects of nutrition and addiction on a learned vocal behavior.Molecular neurobiology · 2011Review
- Dopamine receptors in a songbird brain.The Journal of comparative neurology · 2010Article
- What birdsong can teach us about the central noradrenergic system.Journal of chemical neuroanatomy · 2010Review
- Interplay among catecholamine systems: dopamine binds to alpha2-adrenergic receptors in birds and mammals.The Journal of comparative neurology · 2008Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
A commonly held view is that dopamine exerts its effects via binding to D1- and D2-dopaminergic receptors. However, recent data have emerged supporting the existence of a direct interaction of dopamine with adrenergic but this interaction has been poorly investigated. In this study, the pharmacological basis of possible in vivo interactions between dopamine and alpha(2)-adrenergic receptors was investigated in zebra finches. A binding competition study showed that dopamine displaces the binding of the alpha(2)-adrenergic ligand, [(3)H]RX821002, in the brain. The affinity of dopamine for the adrenergic sites does not differ between the sexes and is 10- to 28-fold lower than that for norepinephrine. To assess the anatomical distribution of this interaction, binding competitions were performed on brain slices incubated in 5nM [(3)H]RX821002 in the absence of any competitor or in the presence of norepinephrine [0.1microM] or dopamine [1microM]. Both norepinephrine and dopamine displaced the binding of the radioligand though to a different extent in most of the regions studied (e.g., area X, the lateral part of the magnocellular nucleus of anterior nidopallium, HVC, arcopallium dorsale, ventral tegmental area and substantia grisea centralis) but not in the robust nucleus of the arcopallium. Together these data provide evidence for a direct interaction between dopamine and adrenergic receptors in songbird brains albeit with regional variation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.