ArticleMechanisms of ageing and development2008
Comparative analysis of microarray data identifies common responses to caloric restriction among mouse tissues.
Article in Mechanisms of ageing and development, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Meta-analysis of age-related gene expression profiles identifies common signatures of aging.Bioinformatics (Oxford, England) · 2009Pooled it
- Trial
- Maternal α-casein deficiency extends the lifespan of offspring and programmes their body composition.GeroScience · 2025Article
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- Dietary Restriction for Kidney Protection: Decline in Nephroprotective Mechanisms During Aging.Frontiers in physiology · 2021Review
- Peroxisome Proliferator-Activated Receptors as Molecular Links between Caloric Restriction and Circadian Rhythm.Nutrients · 2020Review
- Dietary alterations modulate the microRNA 29/30 and IGF-1/AKT signaling axis in breast Cancer liver metastasis.Nutrition & metabolism · 2020Article
- Identification and Application of Gene Expression Signatures Associated with Lifespan Extension.Cell metabolism · 2019Article
- Long-term Dietary Macronutrients and Hepatic Gene Expression in Aging Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- Complementary intestinal mucosa and microbiota responses to caloric restriction.Scientific reports · 2018Article
- Physiological and Transcriptomic Analysis of a Chronologically Long-Lived Saccharomyces cerevisiae Strain Obtained by Evolutionary Engineering.Molecular biotechnology · 2018Article
- Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys.Cell metabolism · 2018Article
- Brain and Hepatic Mt mRNA Is Reduced in Response to Mild Energy Restriction and n-3 Polyunsaturated Fatty Acid Deficiency in Juvenile Rats.Nutrients · 2017Article
- Molecular pathology endpoints useful for aging studies.Ageing research reviews · 2017Review
- mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice.Aging cell · 2017Article
- Calorie restriction regulates circadian clock gene expression through BMAL1 dependent and independent mechanisms.Scientific reports · 2016Article
- Article
- Article
- Arginase I expression is upregulated by dietary restriction in the liver of mice as a function of age.Molecular and cellular biochemistry · 2015Article
- Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Caloric restriction has been extensively investigated as an intervention that both extends lifespan and delays age-related disease in mammals. In mice, much interest has centered on evaluating gene expression changes induced by caloric restriction (CR) in particular tissue types, but the overall systemic effect of CR among multiple tissues has been examined less extensively. This study presents a comparative analysis of microarray datasets that have collectively examined the effects of CR in 10 different tissue types (liver, heart, muscle, hypothalamus, hippocampus, white adipose tissue, colon, kidney, lung and cochlea). Using novel methods for comparative analysis of microarray data, detailed comparisons of the effects of CR among tissues are provided, and 28 genes for which expression response to CR is most shared among tissues are identified. These genes characterize common responses to CR, which consist of both activation and inhibition of stress-response pathways. With respect to liver tissue, transcriptional effects of CR exhibited surprisingly little overlap with those of aging, and a variable degree of overlap with the potential CR-mimetic drug resveratrol. These analyses shed light on the systemic transcriptional activity associated with CR diets, and also illustrate new approaches for comparative analysis of microarray datasets in the context of aging biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.