ArticleDevelopmental biology2008
Notch2 is required for maintaining sustentacular cell function in the adult mouse main olfactory epithelium.
Article in Developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Mechanisms of Neuronal Differentiation and Notch Signaling as a Potential Therapeutic Target in Olfactory Dysfunction of Allergic Rhinitis.Journal of inflammation research · 2025Article
- Manzamine-A Alters In Vitro Calvarial Osteoblast Function.Marine drugs · 2022Article
- Olfactory dysfunction and COVID-19.Operative techniques in otolaryngology--head and neck surgery · 2022Article
- Genome-encoded cytoplasmic double-stranded RNAs, found inScience translational medicine · 2021Article
- The SIX Family of Transcription Factors: Common Themes Integrating Developmental and Cancer Biology.Frontiers in cell and developmental biology · 2021Review
- Article
- Innate immune signaling in the olfactory epithelium reduces odorant receptor levels: modeling transient smell loss in COVID-19 patients.medRxiv : the preprint server for health sciences · 2020Article
- Notch DosageFrontiers in cell and developmental biology · 2020Article
- Jagged1 is Essential for Radial Glial Maintenance in the Cortical Proliferative Zone.Neuroscience · 2019Article
- CanonicalThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Notch1 maintains dormancy of olfactory horizontal basal cells, a reserve neural stem cell.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Contribution of Polycomb group proteins to olfactory basal stem cell self-renewal in a novel c-KIT+ culture model and in vivo.Development (Cambridge, England) · 2016Article
- Inferring data-specific micro-RNA function through the joint ranking of micro-RNA and pathways from matched micro-RNA and gene expression data.Bioinformatics (Oxford, England) · 2015Article
- An endocannabinoid system is present in the mouse olfactory epithelium but does not modulate olfaction.Neuroscience · 2015Article
- Pituitary androgen receptor signalling regulates prolactin but not gonadotrophins in the male mouse.PloS one · 2015Article
- SIX1 promotes epithelial-mesenchymal transition in colorectal cancer through ZEB1 activation.Oncogene · 2012Article
- Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium.PloS one · 2012Article
- Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate.Development (Cambridge, England) · 2011Article
- Inhibition of Notch signaling affects hepatic oval cell response in rat model of 2AAF-PH.Hepatic medicine : evidence and research · 2011Article
- Air-assisted intranasal instillation enhances adenoviral delivery to the olfactory epithelium and respiratory tract.Gene therapy · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Notch receptors are expressed in neurons and glia in the adult nervous system, but why this expression persists is not well-understood. Here we examine the role of the Notch pathway in the postnatal mouse main olfactory system, and show evidence consistent with a model where Notch2 is required for maintaining sustentacular cell function. In the absence of Notch2, the laminar nature of these glial-like cells is disrupted. Hes1, Hey1, and Six1, which are downstream effectors of the Notch pathway, are down-regulated, and cytochrome P450 and Glutathione S-transferase (GST) expression by sustentacular cells is reduced. Functional levels of GST activity are also reduced. These disruptions are associated with increased olfactory sensory neuron degeneration. Surprisingly, expression of Notch3 is also down-regulated. This suggests the existence of a feedback loop where expression of Notch3 is initially independent of Notch2, but requires Notch2 for maintained expression. While the Notch pathway has previously been shown to be important for promoting gliogenesis during development, this is the first demonstration that the persistent expression of Notch receptors is required for maintaining glial function in adult.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.