ArticleSurgery2008
Coordinated, diurnal hexose transporter expression in rat small bowel: implications for small bowel resection.
Article in Surgery, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Daily expression of sodium-dependent glucose cotransporter-1 protein in jejunum during rat ontogeny.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2019Article
- Serum Citrulline Levels Exhibit Circadian Variation and Fluctuations in Relation to Food Intake in Mice.Gastroenterology research · 2019Article
- Skipping breakfast and 5-year changes in body mass index and waist circumference in Japanese men and women.Obesity science & practice · 2017Article
- Circadian regulation of metabolic homeostasis: causes and consequences.Nature and science of sleep · 2016Review
- Nocturnal light exposure alters hepatic Pai-1 expression by stimulating the adrenal pathway in C3H mice.Experimental animals · 2014Article
- Reduction of intestinal electrogenic glucose absorption after duodenojejunal bypass in a mouse model.Obesity surgery · 2013Article
- Disrupted circadian rhythmicity of the intestinal glucose transporter SGLT1 in Zucker diabetic fatty rats.Digestive diseases and sciences · 2013Article
- Diurnal rhythmicity in biological processes involved in bioavailability of functional food factors.Journal of clinical biochemistry and nutrition · 2013Article
- Differentiating passive from transporter-mediated uptake by PepT1: a comparison and evaluation of four methods.The Journal of surgical research · 2011Article
- Absence of evidence of translocation of GLUT2 to the apical membrane of enterocytes in everted intestinal sleeves.The Journal of surgical research · 2011Article
- Role of vagal innervation in diurnal rhythm of intestinal peptide transporter 1 (PEPT1).Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2009Article
- Diurnal expression and function of peptide transporter 1 (PEPT1).The Journal of surgical research · 2009Article
- Expression and function of intestinal hexose transporters after small intestinal denervation.Surgery · 2009Article
- Hexose transporter expression and function in mouse small intestine: role of diurnal rhythm.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2009Article
- Diurnal expression of the rat intestinal sodium-glucose cotransporter 1 (SGLT1) is independent of local luminal factors.Surgery · 2009Article
- Mechanisms of ileal adaptation for glucose absorption after proximal-based small bowel resection.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHexose transporter mRNA and protein levels follow a diurnal rhythm in rat jejunum. Their coordinated expression and resultant function throughout the small bowel is not well understood. We hypothesized that hexose transporter levels and glucose absorption follow a coordinated, site-specific diurnal rhythm in rat duodenum and jejunum, but not in ileum.
methodsSprague-Dawley rats were housed in a strictly maintained, 12-h, light/dark room [light 6 am to 6 pm] with free access to water and chow. Mucosa was harvested from duodenum, jejunum, and ileum at 3 am, 9 am, 3 pm, and 9 pm, and full thickness 1-cm segments were harvested at 9 am, and 9 pm (n = 6 for each segment at each time point). mRNA levels were determined by reverse-transcription, real-time polymerase chain reaction (n > or = 5), protein levels by semiquantitative Western blotting (n > or = 5), and transporter-mediated glucose uptake by everted sleeve technique (n = 6).
resultsmRNA levels of SGLT1 and GLUT5 followed a temporally coordinated, diurnal rhythm in all 3 segments (P < .01), while mRNA for GLUT2 and protein levels for SGLT1 and GLUT2 varied diurnally only in duodenum and jejunum (P > .05) but not in ileum (P > .10). SGLT1 and GLUT5 mRNA induction decreased aborally. Baseline SGLT1 and GLUT5 mRNA levels and SLGT1 and GLUT2 protein levels did not vary aborally (P > .05 for all). GLUT2 mRNA baseline levels were decreased in ileum (P < .01). Glucose uptake varied diurnally in duodenum and jejunum with no difference in ileum. Transporter-mediated glucose uptake was greater in duodenum and jejunum compared with ileum.
conclusionRegulation of hexose absorption in rat small bowel seems to be site-specific and mediated by multiple mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.