Evidence map›Paper›PMID 18154865›Full record

ReviewDental clinics of North America2008

Management of oral mucositis in patients who have cancer.

Rajesh V Lalla, Stephen T Sonis, Douglas E Peterson

3 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Dental clinics of North America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 207 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
207citing papers in PubMed, 18 pooled it
15.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02105740 nacompletednot on this mapstarted 2015, after this paper: background citation

Hypnosis as a Complementary Practice in Pain Management, Anxiety and Depression in Oncological Patients

TypeinterventionalSponsorGil MontenegroRan2015 to 2016Enrolled24ConditionsPain, Depression Anxiety DisorderArmsHypnosis, Control
NCT04308161 phase2unknown statusnot on this mapstarted 2019, after this paper: background citation

The Effectiveness of Topical Oral Vitamin D Gel in Prevention of Radiation-induced Oral Mucositis

TypeinterventionalSponsorHams Hamed AbdelrahmanRan2019 to 2020Enrolled45ConditionsOral Mucositis Due to RadiationArmsvitamin D oral gel, Miconazole Topical Gel, BBC oral spray, Oracure gel, Alkamisr sachets
NCT07736495 phase2 / phase3recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of the Protective Effect of Alpha-Lipoic Acid Against 5-Fluorouracil-Induced Oral Mucositis in Colorectal Cancer Patients

TypeinterventionalSponsorAin Shams UniversityRan2026 to 2026Enrolled50ConditionsColorectal CancerArmsalpha lipoic acid 600 mg twice daily, Placebo Tablet
3 · Its place in the literature

Who cites it

207 citing papers in PubMed, 18 syntheses or guidelines pooled it, 594 citations in OpenAlex.

  1. Pooled it
  2. Systematic review of prophylactic antibacterial agents for radiation-induced oral mucositis in head and neck cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. The impact of oral health education on the incidence and severity of oral mucositis in pediatric cancer patients: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
  7. Efficacy of oral and topical antioxidants in the prevention and management of oral mucositis in head and neck cancer patients: a systematic review and meta-analyses.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
  8. Pooled it
  9. Pooled it
  10. Effectiveness of glutamine in the management of oral mucositis in cancer patients: a meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Systematic review of basic oral care for the management of oral mucositis in cancer patients and clinical practice guidelines.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Pooled it
  15. Meta-analysis of randomized controlled trials of the efficacy of propolis mouthwash in cancer therapy-induced oral mucositis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
    Pooled it
  16. Guideline
  17. Pooled it
  18. A systematic review with meta-analysis of the effect of low-level laser therapy (LLLT) in cancer therapy-induced oral mucositis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2011
    Pooled it
  19. Trial
  20. Trial

147 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Rajesh V LallaDivision of Oral Medicine, Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center MC 1605, 263 Farmington Avenue, Farmington, CT 06030, USA. lalla@nso2.uchc.edu
Stephen T Sonis
Douglas E Peterson
UConn Health · USDana-Farber Brigham Cancer Center · US

Funding

COX-2 Inhibition in Radiation-induced Oral MucositisK23DE016946 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LALLA, RAJESH V. · 2005 to 2009
$692k
NIDCR NIH HHS K23 DE016946NIDCR NIH HHS K23DE016946
6 · The paper itself

Abstract

Oral mucositis is a clinically important and sometimes dose-limiting complication of cancer therapy. Mucositis lesions can be painful, affect nutrition and quality of life, and have a significant economic impact. The pathogenesis of oral mucositis is multifactorial and complex. This review discusses the morbidity, economic impact, pathogenesis and clinical course of mucositis. Current clinical management of oral mucositis is largely focused on palliative measures such as pain management, nutritional support and maintenance of good oral hygiene. However, several promising therapeutic agents are in various stages of clinical development for the management of oral mucositis. These agents are discussed in the context of recently updated evidence-based clinical management guidelines.

Indexed as

Anti-Inflammatory AgentsAntineoplastic AgentsAntioxidantsFacial PainHead and Neck NeoplasmsHumansIntercellular Signaling Peptides and ProteinsMouth MucosaOral HemorrhageRadiation InjuriesRadiotherapyStomatitisXerostomiaAnti-Inflammatory AgentsAntineoplastic AgentsAntioxidantsIntercellular Signaling Peptides and Proteins

Identifiers

PMID18154865
PMCPMC2266835
OpenAlexW384745426

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.