ArticleFEBS letters2008
High affinity selenium uptake in a keratinocyte model.
Article in FEBS letters, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HTJournal of medicinal chemistry · 2024Article
- Review
- Copper coordination compounds with (5RSC advances · 2022Article
- Intracellular HINT1-Assisted Hydrolysis of Nucleoside 5'-International journal of molecular sciences · 2022Article
- Selenium and hydrogen selenide: essential micronutrient and the fourth gasotransmitter?Intensive care medicine experimental · 2019Review
- Uptake and Utilization of Selenium from Selenoprotein P.Biological trace element research · 2018Article
- Cytotoxic activity of selenosulfate versus selenite in tumor cells depends on cell line and presence of amino acids.Environmental science and pollution research international · 2016Article
- Algae and humans share a molybdate transporter.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Jen1p: a high affinity selenite transporter in yeast.Molecular biology of the cell · 2010Article
- Uptake of selenite by Saccharomyces cerevisiae involves the high and low affinity orthophosphate transporters.The Journal of biological chemistry · 2010Article
- Extracellular thiol-assisted selenium uptake dependent on the x(c)- cystine transporter explains the cancer-specific cytotoxicity of selenite.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Inhibition of selenium metabolism in the oral pathogen Treponema denticola.Journal of bacteriology · 2009Article
- Arsenic trioxide and auranofin inhibit selenoprotein synthesis: implications for chemotherapy for acute promyelocytic leukaemia.British journal of pharmacology · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The distribution of selenium in mammals has been recently shown to be mediated primarily by selenoprotein P. Even in the absence of selenoprotein P, selenium is distributed from the liver into all organs and tissues when supplemented in the diet. The form of selenium that is actively taken up by mammalian cells at trace concentrations has yet to be determined. We used a human keratinocyte model to determine whether reduction of the oxyanion selenite (SeO(3)(2-)) to the more reduced form of selenide (HSe(-)) would affect uptake. Indeed a reduced form of selenium, presumably selenide, was actively transported into keratinocytes and displayed saturation kinetics with an apparent K(m) of 279 nM. ATPase inhibitors blocked the uptake of selenide, as did the competing anions molybdate and chromate, but not sulfate. These results suggest that the small molecule form of selenium that is distributed in tissues is hydrogen selenide, despite its sensitivity to oxygen and reactivity to thiols.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.