ArticleBMC evolutionary biology2007
Conserved and species-specific alternative splicing in mammalian genomes.
Article in BMC evolutionary biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Pervasive non-triplet alternative splicing drives functional isoform diversity.Nature communications · 2026Article
- Meta-EA: a gene-specific combination of available computational tools for predicting missense variant effects.Nature communications · 2025Article
- Alternative Splicing Increases Sirtuin Gene Family Diversity and Modulates Their Subcellular Localization and Function.International journal of molecular sciences · 2021Article
- Computational identification and validation of alternative splicing in ZSF1 rat RNA-seq data, a preclinical model for type 2 diabetic nephropathy.Scientific reports · 2018Article
- OMGene: mutual improvement of gene models through optimisation of evolutionary conservation.BMC genomics · 2018Article
- Multi-species sequence comparison reveals conservation of ghrelin gene-derived splice variants encoding a truncated ghrelin peptide.Endocrine · 2016Article
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- Complex tissue-specific patterns and distribution of multiple RAGE splice variants in different mammals.Genome biology and evolution · 2013Article
- Origin and evolution of spliceosomal introns.Biology direct · 2012Review
- Major chimpanzee-specific structural changes in sperm development-associated genes.Functional & integrative genomics · 2011Article
- Constant splice-isoform ratios in human lymphoblastoid cells support the concept of a splico-stat.Genetics · 2011Article
- Evolution of prokaryotic genes by shift of stop codons.Journal of molecular evolution · 2011Article
- Assessment of orthologous splicing isoforms in human and mouse orthologous genes.BMC genomics · 2010Article
- Rodent-specific alternative exons are more frequent in rapidly evolving genes and in paralogs.BMC evolutionary biology · 2009Article
- Alternative splicing of the murine receptor for advanced glycation end-products (RAGE) gene.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
- Sex-specific splicing in Drosophila: widespread occurrence, tissue specificity and evolutionary conservation.Genetics · 2009Article
- The effect of intron length on exon creation ratios during the evolution of mammalian genomes.RNA (New York, N.Y.) · 2008Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlternative splicing has been shown to be one of the major evolutionary mechanisms for protein diversification and proteome expansion, since a considerable fraction of alternative splicing events appears to be species- or lineage-specific. However, most studies were restricted to the analysis of cassette exons in pairs of genomes and did not analyze functionality of the alternative variants.
resultsWe analyzed conservation of human alternative splice sites and cassette exons in the mouse and dog genomes. Alternative exons, especially minor-isofom ones, were shown to be less conserved than constitutive exons. Frame-shifting alternatives in the protein-coding regions are less conserved than frame-preserving ones. Similarly, the conservation of alternative sites is highest for evenly used alternatives, and higher when the distance between the sites is divisible by three. The rate of alternative-exon and site loss in mouse is slightly higher than in dog, consistent with faster evolution of the former. The evolutionary dynamics of alternative sites was shown to be consistent with the model of random activation of cryptic sites.
conclusionConsistent with other studies, our results show that minor cassette exons are less conserved than major-alternative and constitutive exons. However, our study provides evidence that this is caused not only by exon birth, but also lineage-specific loss of alternative exons and sites, and it depends on exon functionality.
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