ArticleBehavioral and brain functions : BBF2007
A lesson not learned: allele misassignment.
Article in Behavioral and brain functions : BBF, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Comparative genetic architectures of schizophrenia in East Asian and European populations.Nature genetics · 2019Article
- PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scores.BMC bioinformatics · 2018Article
- Investigating the association of rs2910164 with cancer predisposition in an Irish cohort.Endocrine connections · 2017Article
- A first insight into population structure and linkage disequilibrium in the US peanut minicore collection.Genetica · 2011Article
- Linkage disequilibrium based association mapping of fiber quality traits in G. hirsutum L. variety germplasm.Genetica · 2009Article
- Application of association mapping to understanding the genetic diversity of plant germplasm resources.International journal of plant genomics · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Misassigned alleles can annihilate efforts to control quality in otherwise well-designed genetic association analyses. To date, the issue remains underreported, as is exemplified by studies of a diallelic DRD2 missense variant in schizophrenia. For this variant, allele frequency data have been either misassigned, or incorrectly cited on four consecutive occasions. Contrary to conjecture, low heterozygosity has not guarded against the error with regard to rs1801028, a SNP that features a canonical base pair transversion, G:C. Measures are discussed that may help to identify misassigned alleles, and to avoid related perils pending more systematic investigation of this confounder in genotype-phenotype associations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.