ArticleBMC cancer2007
The expression of HSP27 is associated with poor clinical outcome in intrahepatic cholangiocarcinoma.
Article in BMC cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Profile of Serum Heat Shock Protein-27 Level in Patients with Salivary Gland Tumor.Journal of dentistry (Shiraz, Iran) · 2022Article
- Review
- The Role of Hsp27 in Chemotherapy Resistance.Biomedicines · 2022Review
- Overexpression of heat-shock factor 1 is associated with a poor prognosis in esophageal squamous cell carcinoma.Oncology letters · 2017Article
- The Prognostic Role of Mitotic Index in Hepatocellular Carcinoma Patients after Curative Hepatectomy.Cancer research and treatment · 2016Article
- Heat shock response associated with hepatocarcinogenesis in a murine model of hereditary tyrosinemia type I.Cancers · 2014Article
- Impact of hyperthermic intraperitoneal chemotherapy on Hsp27 protein expression in serum of patients with peritoneal carcinomatosis.Cell stress & chaperones · 2013Article
- The expression and clinical significance of CLIC1 and HSP27 in lung adenocarcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2011Article
- Markers of bile duct tumors.World journal of gastrointestinal oncology · 2011Article
- Identification of potential biomarkers for giant cell tumor of bone using comparative proteomics analysis.The American journal of pathology · 2011Article
- Differential heat shock protein localization in chronic lymphocytic leukemia.Journal of leukocyte biology · 2010Article
- Heat shock protein 27 as a new therapeutic target for radiation sensitization of head and neck squamous cell carcinoma.Molecular therapy : the journal of the American Society of Gene Therapy · 2009Article
- Expression of heat shock protein 27 and alpha-crystallins in human retinoblastoma after chemoreduction.The British journal of ophthalmology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe heat shock proteins (HSPs) 27-kDa (HSP27) and 72-kDa (HSP72), are ubiquitous chaperone molecules inducible in cells exposed to different stress conditions. Increased level of HSPs are reported in several human cancers, and found to be associated with the resistance to some anticancer treatments and poor prognosis. However, there is no study of the relationship between HSPs expression and patient's prognosis in intrahepatic cholangiocarcinoma (IHCCA). In this exploratory retrospective study, we investigated the expressions of HSP27 and HSP72 as potential prognostic factors in IHCCA.
methodsThirty-one paraffin-embedded samples were analyzed by immunohistochemical methods using HSP27 and HSP72 monoclonal antibodies. Proliferation rate was assessed in the same specimens by using monoclonal antibody against phosphorylated histone H3 (pHH3). Fisher's exact test was used to assess the hypothesis of independence between categorical variables in 2 x 2 tables. The ANOVA procedure was used to evaluate the association between ordinal and categorical variables. Estimates of the survival probability were calculated using the Kaplan-Meier method, and the log rank test was employed to test the null hypothesis of equality in overall survival among groups. The hazard ratio associated with HSP27 and HSP72 expression was estimated by Cox hazard-proportional regression.
resultsThe expression of HSP27 was related to mitotic index, tumor greatest dimension, capsular and vascular invasion while the expression of HSP72 was only related to the presence of necrosis and the lymphoid infiltration. Kaplan-Maier analysis suggested that the expression of HSP27 significantly worsened the patients' median overall survival (11 +/- 3.18 vs 55 +/- 4.1 months, P-value = 0.0003). Moreover HSP27-positive patients exhibited the worst mean survival (7.0 +/- 3.2 months) in the absence of concomitant HSP72 expression.
conclusionThe expression of HSP27, likely increasing cell proliferation, tumor mass, vascular and capsular invasion, might promote aggressive tumor behaviour in IHCCA and decrease patients' survival. Immunohistochemical detection of HSP27 on routine sections may provide a reliable prognostic marker for IHCCA able to influence the therapeutic strategies for this cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.