ReviewImmunology2008
Special regulatory T-cell review: FOXP3 biochemistry in regulatory T cells--how diverse signals regulate suppression.
Review in Immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 88 citations in OpenAlex.
- Shared genetic architecture between COVID-19 and irritable bowel syndrome: a large-scale genome-wide cross-trait analysis.Frontiers in immunology · 2024Article
- Metabolic Choice Tunes Foxp3+ Regulatory T Cell Function.Advances in experimental medicine and biology · 2021Article
- Effects of tumor metabolic microenvironment on regulatory T cells.Molecular cancer · 2018Review
- Microenvironment Cell Contribution to Lymphoma Immunity.Frontiers in oncology · 2018Review
- Curcumin improves regulatory T cells in gut-associated lymphoid tissue of colitis mice.World journal of gastroenterology · 2016Article
- Cyclic adenosine monophosphate involvement in low-dose cyclophosphamide-reversed immune evasion in a mouse lymphoma model.Cellular & molecular immunology · 2012Article
- Regulation generation: the suppressive functions of human regulatory T cells.Critical reviews in immunology · 2012Review
- Immune regulation by histone deacetylases: a focus on the alteration of FOXP3 activity.Immunology and cell biology · 2012Review
- The dual role of the X-linked FoxP3 gene in human cancers.Molecular oncology · 2011Review
- LIF in the regulation of T-cell fate and as a potential therapeutic.Genes and immunity · 2011Review
- Adenosine signaling via the adenosine 2B receptor is involved in bronchiolitis obliterans development.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2010Article
- Thymic changes after chorioamnionitis induced by intraamniotic lipopolysaccharide in fetal sheep.American journal of obstetrics and gynecology · 2010Article
- Cbl- and Nedd4-family ubiquitin ligases: balancing tolerance and immunity.Immunologic research · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
FOXP3 is an acetylated and phosphorylated protein active in human regulatory T cells and forms oligomers which then associate with an even larger molecular complex. FOXP3 actively regulates transcription by recruiting enzymatic co-repressors and/or co-activators. FOXP3 complex ensembles are dynamically regulated by physiological stimuli such as T-cell receptor, IL-2 and proinflammation cytokine signals. Understanding the post-translational modifications of FOXP3 regulated by diverse signals and the biochemistry and structural chemistry of enzymatic proteins in the FOXP3 complex is critical for therapeutically modulating regulatory T cell function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.