ArticleJournal of autoimmunity1991
Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement.
Article in Journal of autoimmunity, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 137 citations in OpenAlex.
- In search of chondrocyte-specific antigen.Central-European journal of immunology · 2018Article
- Rheumatoid arthritis: identifying and characterising polymorphisms using rat models.Disease models & mechanisms · 2016Review
- Induction of bone loss in DBA/1J mice immunized with citrullinated autologous mouse type II collagen in the absence of adjuvant.Immunologic research · 2014Article
- Animal models used to examine the role of the environment in the development of autoimmune disease: findings from an NIEHS Expert Panel Workshop.Journal of autoimmunity · 2012Review
- Identification of two new arthritis severity loci that regulate levels of autoantibodies, interleukin-1β, and joint damage in pristane- and collagen-induced arthritis.Arthritis and rheumatism · 2012Article
- Environmental and gene-environment interactions and risk of rheumatoid arthritis.Rheumatic diseases clinics of North America · 2012Review
- Usage of skin care products and risk of rheumatoid arthritis: results from the Swedish EIRA study.Arthritis research & therapy · 2012Article
- Gait analysis in rats with single joint inflammation: influence of experimental factors.PloS one · 2012Article
- The value of animal models in predicting genetic susceptibility to complex diseases such as rheumatoid arthritis.Arthritis research & therapy · 2009Review
- Quantitative dynamic models of arthritis progression in the rat.Pharmaceutical research · 2009Article
- Lessons from animal models of arthritis over the past decade.Arthritis research & therapy · 2009Review
- Chitosan solution enhances both humoral and cell-mediated immune responses to subcutaneous vaccination.Vaccine · 2007Article
- Article
- Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity.Arthritis research & therapy · 2005Article
- Association between occupational exposure to mineral oil and rheumatoid arthritis: results from the Swedish EIRA case-control study.Arthritis research & therapy · 2005Article
- Adjuvant oil induces waves of arthritogenic lymph node cells prior to arthritis onset.Clinical and experimental immunology · 2004Article
- Induction of experimental autoimmune encephalomyelitis in Dark Agouti rats without adjuvant.Clinical and experimental immunology · 2004Article
- A comparative genetic analysis between collagen-induced arthritis and pristane-induced arthritis.Arthritis and rheumatism · 2003Article
- Neural immune pathways and their connection to inflammatory diseases.Arthritis research & therapy · 2003Review
- The development and use of vaccine adjuvants.Molecular biotechnology · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An intradermal injection of Freund's incomplete adjuvant oil (FIA) without further additives was shown to induce erosive polyarthritis in dark Agouti (DA) rats, but not in Lewis rats. Histological examination revealed joint inflammation, first with polymorphonuclear cells and synovial hyperplasia, and subsequently, with multinucleated giant cells. Both constituents of FIA, mineral oil and Arlacel A, as well as Pristane oil were arthritogenic, whereas vegetable oil were not. Re-administration of adjuvant oil after recovery failed to induce arthritis, thus making possible a role of specific immunity in this new form of arthritis in rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.