Evidence map›Paper›PMID 18098352›Full record

ArticleMagnetic resonance in chemistry : MRC2007

Membrane orientation of the Na,K-ATPase regulatory membrane protein CHIF determined by solid-state NMR.

Carla M Franzin, Peter Teriete, Francesca M Marassi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in chemistry : MRC, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Carla M FranzinBurnham Institute for Medical Research, La Jolla, CA 92037, USA.
Peter Teriete
Francesca M Marassi
Sanford Burnham Prebys Medical Discovery Institute · USInstitute for Medical Research · US

Funding

Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael Jackson · 1985 to 2026
$107.2M
RESOURCE FOR SOLID STATE NMR OF PROTEINSP41EB002031 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI OPELLA, STANLEY J · 2003 to 2018
$16.3M
Structure of Mammary Tumor Mat8 and the FXYD proteinsR01CA082864 · NCI · BURNHAM INSTITUTE FOR MEDICAL RESEARCH · PI MARASSI, FRANCESCA M · 2001 to 2005
$1.5M
NCI NIH HHS P30 CA030199NCI NIH HHS P30CA030199NCI NIH HHS R01 CA082864NCI NIH HHS R01CA082864NIBIB NIH HHS P41 EB002031NIBIB NIH HHS P41EB002031
6 · The paper itself

Abstract

Corticosteroid hormone-induced factor (CHIF) is a major regulatory subunit of the Na,K-ATPase, and a member of an evolutionarily conserved family of membrane proteins that regulate the function of the enzyme complex in a tissue-specific and physiological-state-specific manner. Here we present the structure of CHIF oriented in the membrane, determined by solid-state NMR orientation-dependent restraints. Because CHIF adopts a similar structure in lipid micelles and bilayers, it is possible to assign the solid-state NMR spectrum measured for (15)N-labeled CHIF in oriented bilayers from the structure determined in micelles, to obtain the global orientation of the protein in the membrane.

Indexed as

Cell MembraneHumansLipid BilayersMembrane ProteinsMicellesNuclear Magnetic Resonance, BiomolecularProtein Conformationcorticosteroid hormone-induced factorLipid BilayersMembrane ProteinsMicelles

Identifiers

PMID18098352
PMCPMC2920893
OpenAlexW2084048044

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.