ReviewRadiation and environmental biophysics2008
Systems biological and mechanistic modelling of radiation-induced cancer.
Review in Radiation and environmental biophysics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Mechanistic Modelling of Radiation Responses.Cancers · 2019Review
- The role of dose rate in radiation cancer risk: evaluating the effect of dose rate at the molecular, cellular and tissue levels using key events in critical pathways following exposure to low LET radiation.International journal of radiation biology · 2016Review
- Comparative Risk Predictions of Second Cancers After Carbon-Ion Therapy Versus Proton Therapy.International journal of radiation oncology, biology, physics · 2016Article
- A generalized target theory and its applications.Scientific reports · 2015Article
- CLIP2 as radiation biomarker in papillary thyroid carcinoma.Oncogene · 2015Article
- Imaging for appendicitis: should radiation-induced cancer risks affect modality selection?Radiology · 2014Article
- Secondary sarcoma of bone post-prostate brachytherapy: A case report.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2014Article
- Sex differences in the incidence of chronic myeloid leukemia.Radiation and environmental biophysics · 2014Article
- New approaches to radiation protection.Frontiers in oncology · 2014Review
- Patients with testicular cancer undergoing CT surveillance demonstrate a pitfall of radiation-induced cancer risk estimates: the timing paradox.Radiology · 2013Article
- Lung cancer mortality in the European uranium miners cohorts analyzed with a biologically based model taking into account radon measurement error.Radiation and environmental biophysics · 2012Article
- Review
- New stochastic carcinogenesis model with covariates: an approach involving intracellular barrier mechanisms.Mathematical biosciences · 2012Article
- Models of carcinogenesis: an overview.Carcinogenesis · 2010Review
- Modeling progression in radiation-induced lung adenocarcinomas.Radiation and environmental biophysics · 2010Article
- Use of the individual data of the A-bomb survivors for biologically based cancer models.Radiation and environmental biophysics · 2010Article
- Modeling excess lung cancer risk among screened arm participants in the Mayo Lung Project.Cancer · 2010Article
- The first international workshop on systems radiation biology: a new approach to solve old questions.Radiation and environmental biophysics · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper summarises the five presentations at the First International Workshop on Systems Radiation Biology that were concerned with mechanistic models for carcinogenesis. The mathematical description of various hypotheses about the carcinogenic process, and its comparison with available data is an example of systems biology. It promises better understanding of effects at the whole body level based on properties of cells and signalling mechanisms between them. Of these five presentations, three dealt with multistage carcinogenesis within the framework of stochastic multistage clonal expansion models, another presented a deterministic multistage model incorporating chromosomal aberrations and neoplastic transformation, and the last presented a model of DNA double-strand break repair pathways for second breast cancers following radiation therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.