ArticleDiabetologia2008
Fatty acid-induced mitochondrial uncoupling in adipocytes is not a promising target for treatment of insulin resistance unless adipocyte oxidative capacity is increased.
Article in Diabetologia, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Metabolic characteristics of human subcutaneous abdominal adipose tissue after overnight fast.American journal of physiology. Endocrinology and metabolism · 2012Pooled it
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- Roles of Twist1 in lipid and glucose metabolism.Cell communication and signaling : CCS · 2023Review
- Palmitate induces DNA damage and senescence in human adipocytes in vitro that can be alleviated by oleic acid but not inorganic nitrate.Experimental gerontology · 2022Article
- Increased mitochondrial respiration of adipocytes from metabolically unhealthy obese compared to healthy obese individuals.Scientific reports · 2020Article
- Bisphenol AF promotes inflammation in human white adipocytes.American journal of physiology. Cell physiology · 2020Article
- Saturated Fatty Acids in Obesity-Associated Inflammation.Journal of inflammation research · 2020Review
- Rosiglitazone remodels the lipid droplet and britens human visceral and subcutaneous adipocytes ex vivo.Journal of lipid research · 2019Article
- Altered mitochondrial function in insulin-deficient and insulin-resistant states.The Journal of clinical investigation · 2018Review
- Palmitoleic acid (16:1n7) increases oxygen consumption, fatty acid oxidation and ATP content in white adipocytes.Lipids in health and disease · 2018Article
- Article
- Fasting rapidly increases fatty acid oxidation in white adipose tissue of young broiler chickens.Adipocyte · 2017Article
- Exercise Training Attenuates the Dysregulated Expression of Adipokines and Oxidative Stress in White Adipose Tissue.Oxidative medicine and cellular longevity · 2017Review
- Oxidative stress and metabolic pathologies: from an adipocentric point of view.Oxidative medicine and cellular longevity · 2014Review
- Exercise training enhances white adipose tissue metabolism in rats selectively bred for low- or high-endurance running capacity.American journal of physiology. Endocrinology and metabolism · 2013Article
- NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytes.The Journal of biological chemistry · 2012Article
- Dietary manipulation reveals an unexpected inverse relationship between fat mass and adipose 11β-hydroxysteroid dehydrogenase type 1.American journal of physiology. Endocrinology and metabolism · 2011Article
- Endotoxin mediated-iNOS induction causes insulin resistance via ONOO⁻ induced tyrosine nitration of IRS-1 in skeletal muscle.PloS one · 2010Article
- Article
- The role of mitochondria in the pathogenesis of type 2 diabetes.Endocrine reviews · 2010Review
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The release of fatty acids from white adipose tissue is regulated at several levels. We have examined the suggestion that fatty acid release might be diminished by upregulation of mitochondrial fatty acid oxidation in the adipocyte, through increasing mitochondrial uncoupling. The intrinsic oxidative capacity of white adipose tissue is low, and older studies suggest that there is little fatty acid oxidation in white adipocytes, human or rodent. We have examined data on fatty acid metabolism and O(2) consumption in human white adipose tissue in vivo, and conclude that increasing fatty acid oxidation within the oxidative capacity of the tissue would produce only small changes (a few percent) in fatty acid release. The major locus of control of fatty acid release beyond the stimulation of lipolysis is the pathway of fatty acid esterification, already probably targeted by the thiazolidinedione insulin-sensitising agents. An alternative approach would be to upregulate the mitochondrial capacity of the adipocyte. We review proof-of-concept studies in which the phenotype of the white adipocyte has been changed to resemble that of the brown adipocyte by expression of peroxisome proliferator-activated receptor coactivator-1alpha. This increases oxidative capacity and also leads to fatty acid retention through upregulation of glycerol-3-phosphate production, and hence increased fatty acid re-esterification. We conclude that prevention or treatment of insulin resistance through alteration of adipocyte fatty acid handling will require more than a simple alteration of the activity of mitochondrial beta-oxidation within normal limits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.