ArticleDiabetologia2008
Effects of controlled hypoglycaemia on cardiac repolarisation in patients with type 1 diabetes.
Article in Diabetologia, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02778269 (Predicting Hypoglycaemia and Arrhythmias in the Vulnerable Patient With Diabetes and Chronic Kidney Disease - Validation Study), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Predicting Hypoglycaemia and Arrhythmias in the Vulnerable Patient With Diabetes and Chronic Kidney Disease - Validation Study
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Cardiac implications of hypoglycaemia in patients with diabetes - a systematic review.Cardiovascular diabetology · 2013Pooled it
- Effect of hypoglycaemia on measures of myocardial blood flow and myocardial injury in adults with and without type 1 diabetes: A prospective, randomised, open-label, blinded endpoint, cross-over study.Endocrinology, diabetes & metabolism · 2021Trial
- Effects of Hypoglycemia on Cardiovascular Function in Patients with Diabetes.International journal of molecular sciences · 2023Review
- Mean Absolute Relative Difference of Blood Glucose Monitoring Systems and Relationship to ISO 15197.Journal of diabetes science and technology · 2022Article
- Diabetes without Overt Cardiac Disease Is Associated with Markers of Abnormal Repolarization: A Case-Control Study.Life (Basel, Switzerland) · 2022Article
- Autonomic cardiac regulation during spontaneous nocturnal hypoglycemia in children with type 1 diabetes.Pediatric diabetes · 2021Observational
- Precision Medicine and Artificial Intelligence: A Pilot Study on Deep Learning for Hypoglycemic Events Detection based on ECG.Scientific reports · 2020Article
- Hypoglycaemia and cardiac arrhythmias in diabetes.Therapeutic advances in endocrinology and metabolism · 2020Review
- Cardiac Autonomic Regulation and Repolarization During Acute Experimental Hypoglycemia in Type 2 Diabetes.Diabetes · 2017Article
- Risk Factors and Adverse Outcomes of Severe Hypoglycemia in Type 2 Diabetes Mellitus.Diabetes & metabolism journal · 2016Review
- Article
- Update on strategies limiting iatrogenic hypoglycemia.Endocrine connections · 2015Review
- Emerging treatments for post-transplantation diabetes mellitus.Nature reviews. Nephrology · 2015Review
- Rate-of-Change Dependence of the Performance of Two CGM Systems During Induced Glucose Swings.Journal of diabetes science and technology · 2015Article
- Non-ICU hospital care of diabetes mellitus in the elderly population.Current diabetes reports · 2015Review
- Hypo- and Hyperglycemic Alarms: Devices and Algorithms.Journal of diabetes science and technology · 2015Review
- Hypoglycaemia in diabetes mellitus: epidemiology and clinical implications.Nature reviews. Endocrinology · 2014Review
- Electrocardiological features in obesity: the benefits of body surface potential mapping.Cardiorenal medicine · 2014Review
- Inpatient hypoglycemia: a challenge that must be addressed.Current diabetes reports · 2014Article
- Type 1 diabetes and cardiovascular disease.Cardiovascular diabetology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisNocturnal hypoglycaemia may contribute to sudden death in diabetic patients. However, it is not well known why hypoglycaemia makes these patients prone to death.
methodsWe assessed the effects of controlled hypoglycaemia on cardiac repolarisation using novel electrocardiographic descriptors of T-wave and QRS complex morphology in 16 type 1 diabetic patients and eight healthy counterparts. Several electrocardiographic variables characterising repolarisation were analysed from digitised 12-lead electrocardiograms during a euglycaemic and a hypoglycaemic clamp.
resultsHypoglycaemia did not result in significant changes either in the QT interval corrected for heart rate by the nomogram method or in QT dispersion. However, the morphology of the T-wave changed significantly during hypoglycaemia. The T-wave amplitude and area in precordial leads decreased significantly in both groups (p<0.05 to p<0.001). The spatial QRS-T angle (total cosine R to T) (p<0.05) and the height and the width of the T-wave loop (p<0.05 and p<0.01, respectively) were also reduced in the diabetic patients. The changes in the repolarisation parameters did not exhibit any significant association with changes in catecholamine levels or in heart rate variability in either group. CONCLUSIONS/
interpretationHypoglycaemia results in distinct alterations in cardiac repolarisation, which may increase the vulnerability to arrhythmic events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.