ReviewNature clinical practice. Oncology2008
Prognostic false-positivity of the sentinel node in melanoma.
Review in Nature clinical practice. Oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Head and neck melanoma (excluding ocular melanoma): United Kingdom National Multidisciplinary Guidelines.The Journal of laryngology and otology · 2016Guideline
- Sentinel lymph node biopsy followed by lymph node dissection for localised primary cutaneous melanoma.The Cochrane database of systematic reviews · 2015Pooled it
- Surgery for Metastatic Melanoma: an Evolving Concept.Current oncology reports · 2019Review
- Article
- Lymph node dissection for melanoma: where do we stand?Melanoma management · 2017Review
- A review of sentinel lymph node biopsy for thin melanoma.Irish journal of medical science · 2015Review
- Melanoma: MSLT-1--SNB is a biomarker, not a therapeutic intervention.Nature reviews. Clinical oncology · 2014Article
- Melanoma: MSLT-1--putting sentinel lymph node biopsy into context.Nature reviews. Clinical oncology · 2014Article
- Increasing Age Is Associated with Worse Prognostic Factors and Increased Distant Recurrences despite Fewer Sentinel Lymph Node Positives in Melanoma.International journal of surgical oncology · 2012Article
- Importance of tumor load in the sentinel node in melanoma: clinical dilemmas.Nature reviews. Clinical oncology · 2010Review
- Significance of sentinel lymph node biopsy in malignant melanoma: overview of international data.International journal of clinical oncology · 2009Review
- Thick melanoma: prognostic value of positive sentinel nodes.World journal of surgery · 2009Article
- Sentinel node biopsy needs for a suitable therapeutic management of the cutaneous melanoma.Nature clinical practice. Oncology · 2009Article
- The rationale for sentinel-node biopsy in primary melanoma.Nature clinical practice. Oncology · 2008Article
- Sentinel lymph node biopsy in malignant melanoma.BMJ (Clinical research ed.) · 2008Article
- How should we view the results of the Multicenter Selective Lymphadenectomy Trial-1 (MSLT-1)?Annals of surgical oncology · 2008Article
- Controversies in the diagnosis and treatment of early cutaneous melanoma.Journal of medicine and lifeReview
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is a basic tenet of the sentinel lymph-node biopsy procedure that all positive sentinel lymph nodes will inevitably progress to palpable nodal recurrence if not removed. Comparison of survival is, therefore, considered permissible among patients with positive sentinel lymph nodes who undergo early lymphadenectomy with that among patients who have delayed lymphadenectomy for palpable regional node metastasis, providing that survival is calculated from the date of wide local excision of the primary tumor. Here, that fundamental assumption is contested and evidence is presented to show that a positive sentinel lymph node might have no adverse prognostic relevance in up to one-third of patients. Furthermore, in the same patients, progression to palpable nodal disease might not have occurred even if the positive sentinel node had not been removed. The term prognostic false-positivity is used to describe this phenomenon. Such patients are incorrectly up-staged, are given inaccurate prognostic information and can undergo unnecessary completion lymphadenectomy and unnecessary adjuvant therapy.
Indexed as
Identifiers
18097453What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.