ArticleAmerican journal of respiratory cell and molecular biology2008
Nickel alterations of TLR2-dependent chemokine profiles in lung fibroblasts are mediated by COX-2.
Article in American journal of respiratory cell and molecular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Transition metals in angiogenesis - A narrative review.Materials today. Bio · 2023Review
- Differential influence of Streptococcus mitis on host response to metals in reconstructed human skin and oral mucosa.Contact dermatitis · 2020Article
- Article
- Highly heterogeneous, activated, and short-lived regulatory T cells during chronic filarial infection.European journal of immunology · 2014Article
- Analysis of the toll-like receptor 2-2 (TLR2-2) and TLR4 mRNA expression in the intestinal mucosal immunity of broilers fed on diets supplemented with nickel chloride.International journal of environmental research and public health · 2014Article
- Novel aspects on the pathogenesis of Mycoplasma pneumoniae pneumonia and therapeutic implications.Frontiers in microbiology · 2014Review
- Role of hypoxia-inducible factor 1, α subunit and cAMP-response element binding protein 1 in synergistic release of interleukin 8 by prostaglandin E2 and nickel in lung fibroblasts.American journal of respiratory cell and molecular biology · 2013Article
- Host-Viral Interactions: Role of Pattern Recognition Receptors (PRRs) in Human Pneumovirus Infections.Pathogens (Basel, Switzerland) · 2013Article
- Multiple protein kinase pathways mediate amplified IL-6 release by human lung fibroblasts co-exposed to nickel and TLR-2 agonist, MALP-2.Toxicology and applied pharmacology · 2010Article
- The R753Q polymorphism abrogates toll-like receptor 2 signaling in response to human cytomegalovirus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2009Article
- Nickel mobilizes intracellular zinc to induce metallothionein in human airway epithelial cells.American journal of respiratory cell and molecular biology · 2009Article
- Nickel and the microbial toxin, MALP-2, stimulate proangiogenic mediators from human lung fibroblasts via a HIF-1alpha and COX-2-mediated pathway.Toxicological sciences : an official journal of the Society of Toxicology · 2009Article
- Regulation of COX-2 expression and IL-6 release by particulate matter in airway epithelial cells.American journal of respiratory cell and molecular biology · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Particulate matter air pollution (PM) has been linked with chronic respiratory diseases. Real-life exposures are likely to involve a mixture of chemical and microbial stimuli, yet little attention has been paid to the potential interactions between PM components (e.g., Ni) and microbial agents on the development of inflammatory-like conditions in the lung. Using the Toll-like receptor (TLR)-2 agonist MALP-2 as a lipopeptide relevant to microbial colonization, we hypothesized that nickel sensitizes human lung fibroblasts (HLF) for microbial-driven chemokine release through modulation of TLR signaling pathways. NiSO(4) (200 muM) synergistically enhanced CXCL8, yet antagonized CXCL10 mRNA expression and protein release from HLF in response to MALP-2. RT(2)-PCR pathway-focused array results indicated that NiSO(4) exposure did not alter the expression of TLRs or their downstream signaling mediators, yet significantly increased the expression of cyclooxygenase 2 (COX-2). Moreover, when NiSO(4) was given in combination with MALP-2, there was an amplified induction of COX-2 mRNA and protein along with its metabolic product, PGE2, in HLF. The COX-2 inhibitor, NS-398, attenuated NiSO(4) and MALP-2-induced PGE2 and CXCL8 release and partially reversed the NiSO(4)-dependent inhibition of MALP-2-induced CXCL10 release from HLF. These data indicate that NiSO(4) alters the pattern of TLR-2-dependent chemokine release from HLF via a COX-2-mediated pathway. The quantitative and qualitative effects of NiSO(4) on microbial-driven chemokine release from HLF shed new light on how PM-derived metals can exacerbate respiratory diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.