Evidence map›Paper›PMID 18096828›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2008

C-reactive protein inhibits cholesterol efflux from human macrophage-derived foam cells.

Xinwen Wang, Dan Liao, Uddalak Bharadwaj, Min Li, Qizhi Yao, Changyi Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 73 citations in OpenAlex.

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  4. The High-Sensitivity C-Reactive Protein-Albumin-Lymphocyte Index Is a Prognostic Marker for All-Cause and Cardiovascular Mortality in Patients With ST-Elevation Myocardial Infarction.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Xinwen WangMolecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Dan Liao
Uddalak Bharadwaj
Min Li
Qizhi Yao
Changyi Chen
Michael E. DeBakey VA Medical Center · US

Funding

HIV PROTEASE INHIBITORS EFFECT--NENDOTHELIAL DYSFUNCTIONR01HL065916 · NHLBI · EMORY UNIVERSITY · PI CHEN, CHANGYI · 2000 to 2004
$1.8M
Tissue engineering of small diameter vascular graftR01EB002436 · NIBIB · BAYLOR COLLEGE OF MEDICINE · PI CHEN, CHANGYI · 2003 to 2006
$1.8M
Effects of HAART drugs on endothelial dysfunction of pu*R01HL083471 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI CHEN, CHANGYI · 2005 to 2009
$1.8M
Effects of HIV Protease Inhibitors of Endothelial BarrieR01HL072716 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI CHEN, CHANGYI · 2002 to 2005
$1.2M
Influenza HA in SHIV VLPS for mucosal vaccinationR01DE015543 · NIDCR · BAYLOR COLLEGE OF MEDICINE · PI YAO, QIZHI C. · 2003 to 2006
$1.2M
Ginkgo Biloba Enhances Therapeutic HIV VaccinationR21AT003094 · NCCIH · BAYLOR COLLEGE OF MEDICINE · PI YAO, QIZHI C. · 2005 to 2006
$371k
NCCIH NIH HHS AT003094NCCIH NIH HHS R21 AT003094NHLBI NIH HHS HL083471NHLBI NIH HHS HL65916NHLBI NIH HHS HL72716NHLBI NIH HHS R01 HL065916NHLBI NIH HHS R01 HL072716NHLBI NIH HHS R01 HL083471NIBIB NIH HHS EB-002436NIBIB NIH HHS R01 EB002436NIDCR NIH HHS DE15543NIDCR NIH HHS R01 DE015543
6 · The paper itself

Abstract

objectiveThe objective of this study was to determine the effects and potential mechanisms of C-reactive protein (CRP) on cholesterol efflux from human macrophage foam cells, which may play a critical role in atherogenesis. METHODS AND

resultsHuman THP-1 monocytes and peripheral blood mononuclear cells (PBMCs) were preincubated with acetylated LDL and [3H]-cholesterol to form foam cells, which were then treated with apolipoprotein A-I (apoA-I) or HDL for cholesterol efflux assay. Clinically relevant concentrations of CRP significantly reduced cholesterol efflux from THP-1 and PBMCs to apoA-I or HDL. CRP significantly decreased the expression of ATP-binding membrane cassette transporter A-1 (ABCA1) and ABCG1, whereas it increased superoxide anion production. Furthermore, CRP substantially activated ERK1/2 in THP-1-derived foam-like cells. Reducing superoxide anion by antioxidant seleno-L-methionine or SOD mimetic (MnTBAP) effectively abolished the CRP-induced decrease in cholesterol efflux and the expression of ABCA1 and ABCG1. Inhibiting ERK1/2 activation by its specific inhibitor PD98059 or by a dominant negative mutant of ERK2 could also block CRPs action on THP-1 cells.

conclusionsCRP inhibits cholesterol efflux from human foam cells derived from THP-1 and PBMCs in vitro though oxidative stress, ERK1/2 activation, and downregulation of intracellular cholesterol transport molecules ABCA1 and ABCG1.

Indexed as

Analysis of VarianceAntioxidantsAtherosclerosisATP-Binding Cassette TransportersBiological TransportBlotting, WesternCells, CulturedCholesterol EstersC-Reactive ProteinFoam CellsHumansMacrophagesProbabilityReverse Transcriptase Polymerase Chain ReactionSensitivity and SpecificitySuperoxidesAntioxidantsATP-Binding Cassette TransportersCholesterol EstersC-Reactive ProteinSuperoxides

Identifiers

PMID18096828
PMCPMC2927966
OpenAlexW2158894978

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.