ArticleGenome research2008
Genome-wide discovery and verification of novel structured RNAs in Plasmodium falciparum.
Article in Genome research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed.
- Circular RNAs: An Under-Recognized Part in Different Scenarios of Host-Parasite Interrelationships.Pathogens (Basel, Switzerland) · 2026Review
- Comparative and systems analyses of Leishmania spp. non-coding RNAs through developmental stages.PLoS neglected tropical diseases · 2025Article
- RNAcode_Web - Convenient identification of evolutionary conserved protein coding regions.Journal of integrative bioinformatics · 2023Article
- Novel insights into the role of long non-coding RNA in the human malaria parasite, Plasmodium falciparum.Nature communications · 2023Article
- Emerging biology of noncoding RNAs in malaria parasites.PLoS pathogens · 2022Review
- Non-coding RNAs in malaria infection.Wiley interdisciplinary reviews. RNA · 2022Review
- Resetting var Gene Transcription in Plasmodium falciparum.Methods in molecular biology (Clifton, N.J.) · 2022Article
- The RNA structurome in the asexual blood stages of malaria pathogenRNA biology · 2021Article
- Full-Length Transcriptome Analysis ofFrontiers in cellular and infection microbiology · 2021Article
- The cryptic unstable transcripts are associated with developmentally regulated gene expression in blood-stageRNA biology · 2020Article
- Article
- Progression of the canonical reference malaria parasite genome from 2002-2019.Wellcome open research · 2019Article
- Simultaneous genome-wide gene expression and transcript isoform profiling in the human malaria parasite.PloS one · 2017Article
- Trans-acting GC-rich non-coding RNA at var expression site modulates gene counting in malaria parasite.Nucleic acids research · 2016Article
- Recent advances in malaria genomics and epigenomics.Genome medicine · 2016Review
- Antisense long noncoding RNAs regulate var gene activation in the malaria parasite Plasmodium falciparum.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria.Nature · 2014Article
- Noncoding RNAs as emerging regulators of Plasmodium falciparum virulence gene expression.Current opinion in microbiology · 2014Review
- Genome-wide identification and functional annotation of Plasmodium falciparum long noncoding RNAs from RNA-seq data.Parasitology research · 2014Article
- Structural polymorphism in the promoter of pfmrp2 confers Plasmodium falciparum tolerance to quinoline drugs.Molecular microbiology · 2014Article
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Authors and funding
13 authors.
Funding
Abstract
We undertook a genome-wide search for novel noncoding RNAs (ncRNA) in the malaria parasite Plasmodium falciparum. We used the RNAz program to predict structures in the noncoding regions of the P. falciparum 3D7 genome that were conserved with at least one of seven other Plasmodium spp. genome sequences. By using Northern blot analysis for 76 high-scoring predictions and microarray analysis for the majority of candidates, we have verified the expression of 33 novel ncRNA transcripts including four members of a ncRNA family in the asexual blood stage. These transcripts represent novel structured ncRNAs in P. falciparum and are not represented in any RNA databases. We provide supporting evidence for purifying selection acting on the experimentally verified ncRNAs by comparing the nucleotide substitutions in the predicted ncRNA candidate structures in P. falciparum with the closely related chimp malaria parasite P. reichenowi. The high confirmation rate within a single parasite life cycle stage suggests that many more of the predictions may be expressed in other stages of the organism's life cycle.
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