ArticleBiophysical journal2008
Backbone dynamics of alamethicin bound to lipid membranes: spin-echo electron paramagnetic resonance of TOAC-spin labels.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Librational Dynamics of Spin-Labeled Membranes at Cryogenic Temperatures From Echo-Detected ED-EPR Spectra.Frontiers in molecular biosciences · 2022Review
- Evidence for an Ordering Transition near 120 K in an Intrinsically Disordered Protein, Casein.Molecules (Basel, Switzerland) · 2021Article
- Alamethicin Supramolecular Organization in Lipid Membranes fromBiophysical journal · 2016Article
- Lipid Librations at the Interface with the Na,K-ATPase.Biophysical journal · 2015Article
- The spin label amino acid TOAC and its uses in studies of peptides: chemical, physicochemical, spectroscopic, and conformational aspects.Biophysical reviews · 2012Article
- Solvent effect on librational dynamics of spin-labelled haemoglobin by ED- and CW-EPR.European biophysics journal : EBJ · 2011Article
- A spirocyclohexyl nitroxide amino acid spin label for pulsed EPR spectroscopy distance measurements.Chemistry (Weinheim an der Bergstrasse, Germany) · 2010Article
- Spin-Label EPR for Determining Polarity and Proticity in Biomolecular Assemblies: Transmembrane Profiles.Applied magnetic resonance · 2010Article
- Structure of self-aggregated alamethicin in ePC membranes detected by pulsed electron-electron double resonance and electron spin echo envelope modulation spectroscopies.Biophysical journal · 2009Article
- Intramembrane water associated with TOAC spin-labeled alamethicin: electron spin-echo envelope modulation by D2O.Biophysical journal · 2009Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alamethicin F50/5 is a hydrophobic peptide that is devoid of charged residues and that induces voltage-dependent ion channels in lipid membranes. The peptide backbone is likely to be involved in the ion conduction pathway. Electron spin-echo spectroscopy of alamethicin F50/5 analogs in which a selected Aib residue (at position n = 1, 8, or 16) is replaced by the TOAC amino-acid spin label was used to study torsional dynamics of the peptide backbone in association with phosphatidylcholine bilayer membranes. Rapid librational motions of limited angular amplitude were observed at each of the three TOAC sites by recording echo-detected spectra as a function of echo delay time, 2tau. Simulation of the time-resolved spectra, combined with conventional EPR measurements of the librational amplitude, shows that torsional fluctuations of the peptide backbone take place on the subnanosecond to nanosecond timescale, with little temperature dependence. Associated fluctuations in polar fields from the peptide could facilitate ion permeation.
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