ArticleBiophysical journal2008
Experimental and computational studies investigating trehalose protection of HepG2 cells from palmitate-induced toxicity.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Trehalose as an anti-inflammatory agent: insights into molecular mechanisms and therapeutic applications.Inflammopharmacology · 2026Review
- Electron microscopy reveals saturated fatty acid-induced membrane defects in AdipoR2-depleted cells.Lipids in health and disease · 2025Article
- Hepatoprotective Effect of Trehalose: Insight into Its Mechanisms of Action.Advances in experimental medicine and biology · 2021Article
- Bitter melon extract ameliorates palmitate-induced apoptosis via inhibition of endoplasmic reticulum stress in HepG2 cells and high-fat/high-fructose-diet-induced fatty liver.Food & nutrition research · 2018Article
- The adiponectin receptor AdipoR2 and its Caenorhabditis elegans homolog PAQR-2 prevent membrane rigidification by exogenous saturated fatty acids.PLoS genetics · 2017Article
- The protective action of osmolytes on the deleterious effects of gamma rays and atmospheric pressure plasma on protein conformational changes.Scientific reports · 2017Article
- Combination of anti-hypertensive drugs: a molecular dynamics simulation study.Journal of molecular modeling · 2017Article
- Fenretinide induces ubiquitin-dependent proteasomal degradation of stearoyl-CoA desaturase in human retinal pigment epithelial cells.Journal of cellular physiology · 2014Article
- A molecular dynamics approach to ligand-receptor interaction in the aspirin-human serum albumin complex.Journal of biophysics (Hindawi Publishing Corporation : Online) · 2012Article
- The use of trehalose in the preparation of specimens for molecular electron microscopy.Micron (Oxford, England : 1993) · 2011Review
- Polypharmacy, multiple natural health products and hepatotoxicity.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2011Article
- Lipid composition influences the release of Alzheimer's amyloid β-peptide from membranes.Protein science : a publication of the Protein Society · 2011Article
- The role of fatty acid unsaturation in minimizing biophysical changes on the structure and local effects of bilayer membranes.Biochimica et biophysica acta · 2009Article
- Differential effects of a saturated and a monounsaturated fatty acid on MHC class I antigen presentation.Scandinavian journal of immunology · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Understanding the mechanism of saturated fatty acid-induced hepatocyte toxicity may provide insight into cures for diseases such as obesity-associated cirrhosis. Trehalose, a nonreducing disaccharide shown to protect proteins and cellular membranes from inactivation or denaturation caused by different stress conditions, also protects hepatocytes from palmitate-induced toxicity. Our results suggest that trehalose serves as a free radical scavenger and alleviates damage from hydrogen peroxide secreted by the compromised cells. We also observe that trehalose protects HepG2 cells by interacting with the plasma membrane to counteract the changes in membrane fluidity induced by palmitate. The experimental results are supported by molecular dynamics simulations of model cell membranes that closely reflect the experimental conditions. Simulations were performed to understand the specific interactions between lipid bilayers, palmitate, and trehalose. The simulations results reveal the early stages of how palmitate induces biophysical changes to the cellular membrane and the role of trehalose in protecting the membrane structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.